Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats
In recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE) in rats serves as an experimental model for h...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2023/5552740 |
| _version_ | 1797601613700923392 |
|---|---|
| author | Gayane Ghazaryan Hasmik Zanginyan Laura Hovsepyan Artyom Azatyan Maria Ghazaryan Lusine Mardanyan |
| author_facet | Gayane Ghazaryan Hasmik Zanginyan Laura Hovsepyan Artyom Azatyan Maria Ghazaryan Lusine Mardanyan |
| author_sort | Gayane Ghazaryan |
| collection | DOAJ |
| description | In recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE) in rats serves as an experimental model for human multiple sclerosis. Our study elucidates and demonstrates the antioxidant properties of Cronassial, a drug containing gangliosides, on the processes of free radical lipid oxidation and oxidative modification of proteins in the brains and spinal cords of rats with EAE. Our research results reveal an elevated production of oxidative stress products, including peroxides, hydroperoxides, and oxidized proteins, in experimental animals. This phenomenon is one of the factors contributing to myelin damage. Administering a ganglioside-containing drug normalizes the consequences of oxidative stress and inhibits the formation of reactive oxygen species. Consequently, the data obtained highlight the neuroprotective and antioxidant effects of Cronassial when administered to animals with autoimmune encephalomyelitis. |
| first_indexed | 2024-03-11T04:02:50Z |
| format | Article |
| id | doaj.art-8fc2e3503c3942ee9742deb7f0c96457 |
| institution | Directory Open Access Journal |
| issn | 2090-2255 |
| language | English |
| last_indexed | 2024-03-11T04:02:50Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj.art-8fc2e3503c3942ee9742deb7f0c964572023-11-18T00:00:01ZengHindawi LimitedBiochemistry Research International2090-22552023-01-01202310.1155/2023/5552740Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of RatsGayane Ghazaryan0Hasmik Zanginyan1Laura Hovsepyan2Artyom Azatyan3Maria Ghazaryan4Lusine Mardanyan5Institute of Molecular Biology NAS RAInstitute of Molecular Biology NAS RAInstitute of Molecular Biology NAS RAInstitute of Molecular Biology NAS RAInstitute of Molecular Biology NAS RADavidyants LaboratoriesIn recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE) in rats serves as an experimental model for human multiple sclerosis. Our study elucidates and demonstrates the antioxidant properties of Cronassial, a drug containing gangliosides, on the processes of free radical lipid oxidation and oxidative modification of proteins in the brains and spinal cords of rats with EAE. Our research results reveal an elevated production of oxidative stress products, including peroxides, hydroperoxides, and oxidized proteins, in experimental animals. This phenomenon is one of the factors contributing to myelin damage. Administering a ganglioside-containing drug normalizes the consequences of oxidative stress and inhibits the formation of reactive oxygen species. Consequently, the data obtained highlight the neuroprotective and antioxidant effects of Cronassial when administered to animals with autoimmune encephalomyelitis.http://dx.doi.org/10.1155/2023/5552740 |
| spellingShingle | Gayane Ghazaryan Hasmik Zanginyan Laura Hovsepyan Artyom Azatyan Maria Ghazaryan Lusine Mardanyan Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats Biochemistry Research International |
| title | Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats |
| title_full | Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats |
| title_fullStr | Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats |
| title_full_unstemmed | Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats |
| title_short | Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats |
| title_sort | cronassial ameliorates autoimmune encephalomyelitis by inhibiting lipid oxidation and carbonyl stress in the brain and spinal cord of rats |
| url | http://dx.doi.org/10.1155/2023/5552740 |
| work_keys_str_mv | AT gayaneghazaryan cronassialamelioratesautoimmuneencephalomyelitisbyinhibitinglipidoxidationandcarbonylstressinthebrainandspinalcordofrats AT hasmikzanginyan cronassialamelioratesautoimmuneencephalomyelitisbyinhibitinglipidoxidationandcarbonylstressinthebrainandspinalcordofrats AT laurahovsepyan cronassialamelioratesautoimmuneencephalomyelitisbyinhibitinglipidoxidationandcarbonylstressinthebrainandspinalcordofrats AT artyomazatyan cronassialamelioratesautoimmuneencephalomyelitisbyinhibitinglipidoxidationandcarbonylstressinthebrainandspinalcordofrats AT mariaghazaryan cronassialamelioratesautoimmuneencephalomyelitisbyinhibitinglipidoxidationandcarbonylstressinthebrainandspinalcordofrats AT lusinemardanyan cronassialamelioratesautoimmuneencephalomyelitisbyinhibitinglipidoxidationandcarbonylstressinthebrainandspinalcordofrats |