Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function
Abstract Background End‐stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). Aims We aimed to analyze the expression differences of serum thrombomodulin (TM), platelet‐activating factor (PAF), and P‐selectin (CD62P) in patients with autologous arteriovenous fistula (AVF) an...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.1227 |
| _version_ | 1827307563550507008 |
|---|---|
| author | Yan Jiang Zongyang Liu Liting Liu Zhiqian Xiong Yan Chen Shuai Zhang Chaojiang Su |
| author_facet | Yan Jiang Zongyang Liu Liting Liu Zhiqian Xiong Yan Chen Shuai Zhang Chaojiang Su |
| author_sort | Yan Jiang |
| collection | DOAJ |
| description | Abstract Background End‐stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). Aims We aimed to analyze the expression differences of serum thrombomodulin (TM), platelet‐activating factor (PAF), and P‐selectin (CD62P) in patients with autologous arteriovenous fistula (AVF) and the correlation with vascular access function. Methods The case data were retrospectively analyzed. Moreover, 160 patients with AVF maintenance hemodialysis were selected as the AVF group, and 150 healthy participants were selected as the healthy control group. According to the function of vascular access, patients in the AVF group were divided into Group A (n = 50, after the first establishment of AVF), Group B (n = 64, normal vascular access function after hemodialysis treatment), and Group C (n = 46, vascular access failure). Pearson analysis was conducted to explore the correlation between serum TM, PAF, CD62P content, and vascular pathological examination indicators, to evaluate the value of TM, PAF, and CD62P levels in predicting vascular access failure in patients with AVF. Results and Discussion The serum levels of TM, PAF, and CD62P were positively correlated with the expressions of CD68 and MCP‐1, respectively (p < .001). Serum TM was positively correlated with the levels of PAF and CD62P (p < .001), and PAF was positively correlated with the levels of CD62P (p < .001), respectively. Serum levels of TM, PAF and CD62P were risk factors for vascular access failure in AVF patients (p < .05). The area under the curve of serum TM, PAF and CD62P levels in predicting vascular access failure in AVF patients was 0.879. Conclusion The serum levels of TM, PAF, and CD62P in AVF patients were correlated with the vascular access function of AVF patients, which was very important for maintaining the stability of vascular access function, and had certain value in predicting vascular access failure/disorder in AVF patients, and could be popularized and applied. |
| first_indexed | 2024-04-24T18:41:08Z |
| format | Article |
| id | doaj.art-8fc345507cf242d3b6aef65c93afd892 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-04-24T18:41:08Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-8fc345507cf242d3b6aef65c93afd8922024-03-27T12:16:37ZengWileyImmunity, Inflammation and Disease2050-45272024-03-01123n/an/a10.1002/iid3.1227Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access functionYan Jiang0Zongyang Liu1Liting Liu2Zhiqian Xiong3Yan Chen4Shuai Zhang5Chaojiang Su6Department of Nephrology Affiliated Cancer Hospital of Guizhou Medical University Guiyang ChinaDepartment of Nephrology Affiliated Cancer Hospital of Guizhou Medical University Guiyang ChinaSchool of Clinical Medicine Guizhou Medical University Guiyang ChinaSchool of Clinical Medicine Guizhou Medical University Guiyang ChinaDepartment of Nephrology Affiliated Cancer Hospital of Guizhou Medical University Guiyang ChinaDepartment of Interventional Medicine Affiliated Hospital of Guizhou Medical University Guiyang ChinaDepartment of Nephrology Affiliated Cancer Hospital of Guizhou Medical University Guiyang ChinaAbstract Background End‐stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). Aims We aimed to analyze the expression differences of serum thrombomodulin (TM), platelet‐activating factor (PAF), and P‐selectin (CD62P) in patients with autologous arteriovenous fistula (AVF) and the correlation with vascular access function. Methods The case data were retrospectively analyzed. Moreover, 160 patients with AVF maintenance hemodialysis were selected as the AVF group, and 150 healthy participants were selected as the healthy control group. According to the function of vascular access, patients in the AVF group were divided into Group A (n = 50, after the first establishment of AVF), Group B (n = 64, normal vascular access function after hemodialysis treatment), and Group C (n = 46, vascular access failure). Pearson analysis was conducted to explore the correlation between serum TM, PAF, CD62P content, and vascular pathological examination indicators, to evaluate the value of TM, PAF, and CD62P levels in predicting vascular access failure in patients with AVF. Results and Discussion The serum levels of TM, PAF, and CD62P were positively correlated with the expressions of CD68 and MCP‐1, respectively (p < .001). Serum TM was positively correlated with the levels of PAF and CD62P (p < .001), and PAF was positively correlated with the levels of CD62P (p < .001), respectively. Serum levels of TM, PAF and CD62P were risk factors for vascular access failure in AVF patients (p < .05). The area under the curve of serum TM, PAF and CD62P levels in predicting vascular access failure in AVF patients was 0.879. Conclusion The serum levels of TM, PAF, and CD62P in AVF patients were correlated with the vascular access function of AVF patients, which was very important for maintaining the stability of vascular access function, and had certain value in predicting vascular access failure/disorder in AVF patients, and could be popularized and applied.https://doi.org/10.1002/iid3.1227autologous arteriovenous fistulaCD62PPAFTMvascular access function |
| spellingShingle | Yan Jiang Zongyang Liu Liting Liu Zhiqian Xiong Yan Chen Shuai Zhang Chaojiang Su Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function Immunity, Inflammation and Disease autologous arteriovenous fistula CD62P PAF TM vascular access function |
| title | Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function |
| title_full | Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function |
| title_fullStr | Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function |
| title_full_unstemmed | Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function |
| title_short | Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function |
| title_sort | differential expression of serum tm paf and cd62p in patients with autologous arteriovenous fistula and the correlation with vascular access function |
| topic | autologous arteriovenous fistula CD62P PAF TM vascular access function |
| url | https://doi.org/10.1002/iid3.1227 |
| work_keys_str_mv | AT yanjiang differentialexpressionofserumtmpafandcd62pinpatientswithautologousarteriovenousfistulaandthecorrelationwithvascularaccessfunction AT zongyangliu differentialexpressionofserumtmpafandcd62pinpatientswithautologousarteriovenousfistulaandthecorrelationwithvascularaccessfunction AT litingliu differentialexpressionofserumtmpafandcd62pinpatientswithautologousarteriovenousfistulaandthecorrelationwithvascularaccessfunction AT zhiqianxiong differentialexpressionofserumtmpafandcd62pinpatientswithautologousarteriovenousfistulaandthecorrelationwithvascularaccessfunction AT yanchen differentialexpressionofserumtmpafandcd62pinpatientswithautologousarteriovenousfistulaandthecorrelationwithvascularaccessfunction AT shuaizhang differentialexpressionofserumtmpafandcd62pinpatientswithautologousarteriovenousfistulaandthecorrelationwithvascularaccessfunction AT chaojiangsu differentialexpressionofserumtmpafandcd62pinpatientswithautologousarteriovenousfistulaandthecorrelationwithvascularaccessfunction |