PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis

PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis

Aberrant innate immune responses to the gut microbiota are causally involved in the pathogenesis of inflammatory bowel diseases (IBD). The exact triggers and main signaling pathways activating innate immune cells and how they modulate adaptive immunity in IBD is still not completely understood. Here...

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Bibliographic Details
Main Authors: Mario Kuttke, Dominika Hromadová, Ceren Yildirim, Julia S. Brunner, Andrea Vogel, Hannah Paar, Sophie Peters, Maria Weber, Melanie Hofmann, Martina Kerndl, Markus Kieler, Hannes Datler, Laszlo Musiejovsky, Manuel Salzmann, Michaela Lang, Klara Soukup, Angela Halfmann, Omar Sharif, Gernot Schabbauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
PI3K
PTEN
dendritic cells
DSS-induced colitis
Interleukin-6
Th1-response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.695576/full

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