Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective Analysis
Combination of systemic biological and traditional agents is increasingly used for the treatment of “high-need” patients with psoriasis. There are only limited data on the combination of cyclosporine (CsA) with biologicals. We report our experience concerning the use of etanercept in combination wit...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-08-01
|
| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X1201000210 |
| _version_ | 1818240671153127424 |
|---|---|
| author | G.A. Vena V. Mastrandrea S. Battaglini F. Loconsole R. Buquicchio N. Cassano |
| author_facet | G.A. Vena V. Mastrandrea S. Battaglini F. Loconsole R. Buquicchio N. Cassano |
| author_sort | G.A. Vena |
| collection | DOAJ |
| description | Combination of systemic biological and traditional agents is increasingly used for the treatment of “high-need” patients with psoriasis. There are only limited data on the combination of cyclosporine (CsA) with biologicals. We report our experience concerning the use of etanercept in combination with CsA, given at a dose of 3–5mg/kg two days per week, in patients with insufficient response of psoriasisto etanercept monotherapy. The retrospective analysis of 17 patients showed that the addition of CsA for 2–8 months was capable of inducing a relevant clinical benefit in a total of 12 patients. The combination treatment was tolerated by all patients except one who had to stop CsA treatment because of repeated hypertensive crises. |
| first_indexed | 2024-12-12T13:17:09Z |
| format | Article |
| id | doaj.art-8fc4af3a501443588550719dbaeabed4 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-12T13:17:09Z |
| publishDate | 2012-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-8fc4af3a501443588550719dbaeabed42022-12-22T00:23:24ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2012-08-011010.1177/1721727X1201000210Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective AnalysisG.A. Vena0V. Mastrandrea1S. Battaglini2F. Loconsole3R. Buquicchio4N. Cassano5Dermatology Clinic, Department of Biomedical Sciences and Human Oncology, University of Bari, ItalyDermatology Clinic, Department of Biomedical Sciences and Human Oncology, University of Bari, ItalyDermatology Clinic, Department of Biomedical Sciences and Human Oncology, University of Bari, ItalyDermatology Clinic, Department of Biomedical Sciences and Human Oncology, University of Bari, ItalyDermatology Clinic, Department of Biomedical Sciences and Human Oncology, University of Bari, ItalyDermatology Clinic, Department of Biomedical Sciences and Human Oncology, University of Bari, ItalyCombination of systemic biological and traditional agents is increasingly used for the treatment of “high-need” patients with psoriasis. There are only limited data on the combination of cyclosporine (CsA) with biologicals. We report our experience concerning the use of etanercept in combination with CsA, given at a dose of 3–5mg/kg two days per week, in patients with insufficient response of psoriasisto etanercept monotherapy. The retrospective analysis of 17 patients showed that the addition of CsA for 2–8 months was capable of inducing a relevant clinical benefit in a total of 12 patients. The combination treatment was tolerated by all patients except one who had to stop CsA treatment because of repeated hypertensive crises.https://doi.org/10.1177/1721727X1201000210 |
| spellingShingle | G.A. Vena V. Mastrandrea S. Battaglini F. Loconsole R. Buquicchio N. Cassano Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective Analysis European Journal of Inflammation |
| title | Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective Analysis |
| title_full | Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective Analysis |
| title_fullStr | Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective Analysis |
| title_full_unstemmed | Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective Analysis |
| title_short | Combination of Etanercept and Twice-Weekly Administration of Cyclosporin in Psoriasis Unsatisfactorily Controlled by Etanercept Monotherapy: A Retrospective Analysis |
| title_sort | combination of etanercept and twice weekly administration of cyclosporin in psoriasis unsatisfactorily controlled by etanercept monotherapy a retrospective analysis |
| url | https://doi.org/10.1177/1721727X1201000210 |
| work_keys_str_mv | AT gavena combinationofetanerceptandtwiceweeklyadministrationofcyclosporininpsoriasisunsatisfactorilycontrolledbyetanerceptmonotherapyaretrospectiveanalysis AT vmastrandrea combinationofetanerceptandtwiceweeklyadministrationofcyclosporininpsoriasisunsatisfactorilycontrolledbyetanerceptmonotherapyaretrospectiveanalysis AT sbattaglini combinationofetanerceptandtwiceweeklyadministrationofcyclosporininpsoriasisunsatisfactorilycontrolledbyetanerceptmonotherapyaretrospectiveanalysis AT floconsole combinationofetanerceptandtwiceweeklyadministrationofcyclosporininpsoriasisunsatisfactorilycontrolledbyetanerceptmonotherapyaretrospectiveanalysis AT rbuquicchio combinationofetanerceptandtwiceweeklyadministrationofcyclosporininpsoriasisunsatisfactorilycontrolledbyetanerceptmonotherapyaretrospectiveanalysis AT ncassano combinationofetanerceptandtwiceweeklyadministrationofcyclosporininpsoriasisunsatisfactorilycontrolledbyetanerceptmonotherapyaretrospectiveanalysis |