Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1–FGL1–MYH9 axis

Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1–FGL1–MYH9 axis

RationalLung cancer is the most common tumor worldwide, with the highest mortality rate and second highest incidence. Immunotherapy is one of the most important treatments for lung adenocarcinoma (LUAD); however, it has relatively low response rate and high incidence of adverse events. Herein, we ex...

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Bibliographic Details
Main Authors: Xi-Yang Tang, Yan-Lu Xiong, Ya-Bo Zhao, Jie Yang, An-Ping Shi, Kai-Fu Zheng, Yu-Jian Liu, Chen Shu, Tao Jiang, Nan Ma, Jin-Bo Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
immunity
proliferation
FGL1
YY1
MYH9
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1014053/full

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