SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus

SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus

Zika virus (ZIKV) infection suppresses the induction of dendritic cell (DC)-derived immunity, but the underlying mechanistical insights are still lacking. Here the authors show, using in vitro systems profiling of DC transcriptome and epigenome, that ZIKV specifically alters SREBP2-related expressio...

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Bibliographic Details
Main Authors: Emilie Branche, Ying-Ting Wang, Karla M. Viramontes, Joan M. Valls Cuevas, Jialei Xie, Fernanda Ana-Sosa-Batiz, Norazizah Shafee, Sascha H. Duttke, Rachel E. McMillan, Alex E. Clark, Michael N. Nguyen, Aaron F. Garretson, Jan J. Crames, Nathan J. Spann, Zhe Zhu, Jeremy N. Rich, Deborah H. Spector, Christopher Benner, Sujan Shresta, Aaron F. Carlin
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33041-1

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