Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study
Recent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate the causal association between gut microbiota and bio...
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MDPI AG
2024-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/2/370 |
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| author | Chenglin Ye Zhiqiang Li Chun Ye Li Yuan Kailang Wu Chengliang Zhu |
| author_facet | Chenglin Ye Zhiqiang Li Chun Ye Li Yuan Kailang Wu Chengliang Zhu |
| author_sort | Chenglin Ye |
| collection | DOAJ |
| description | Recent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate the causal association between gut microbiota and biological age acceleration using the largest available gut microbiota GWAS summary data from the MiBioGen consortium and GWAS data on biological age acceleration. We further conducted sensitivity analysis using MR-PRESSO, MR-Egger regression, Cochran Q test, and reverse MR analysis. <i>Streptococcus</i> (IVW, β = 0.16, <i>p</i> = 0.0001) was causally associated with Bioage acceleration. <i>Eubacterium</i> (<i>rectale group</i>) (IVW, β = 0.20, <i>p</i> = 0.0190), <i>Sellimonas</i> (IVW, β = 0.06, <i>p</i> = 0.019), and <i>Lachnospira</i> (IVW, β = −0.18, <i>p</i> = 0.01) were suggestive of causal associations with Bioage acceleration, with the latter being protective. <i>Actinomyces</i> (IVW, β = 0.26, <i>p</i> = 0.0083), <i>Butyricimonas</i> (IVW, β = 0.21, <i>p</i> = 0.0184), and <i>Lachnospiraceae</i> (<i>FCS020 group</i>) (IVW, β = 0.24, <i>p</i> = 0.0194) were suggestive of causal associations with Phenoage acceleration. This Mendelian randomization study found that <i>Streptococcus</i> was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process. |
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| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-07T22:21:01Z |
| publishDate | 2024-02-01 |
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| series | Microorganisms |
| spelling | doaj.art-8fc7a5503dc04ba592d2f6be96b700612024-02-23T15:28:21ZengMDPI AGMicroorganisms2076-26072024-02-0112237010.3390/microorganisms12020370Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization StudyChenglin Ye0Zhiqiang Li1Chun Ye2Li Yuan3Kailang Wu4Chengliang Zhu5Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, ChinaDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430060, ChinaState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaRecent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate the causal association between gut microbiota and biological age acceleration using the largest available gut microbiota GWAS summary data from the MiBioGen consortium and GWAS data on biological age acceleration. We further conducted sensitivity analysis using MR-PRESSO, MR-Egger regression, Cochran Q test, and reverse MR analysis. <i>Streptococcus</i> (IVW, β = 0.16, <i>p</i> = 0.0001) was causally associated with Bioage acceleration. <i>Eubacterium</i> (<i>rectale group</i>) (IVW, β = 0.20, <i>p</i> = 0.0190), <i>Sellimonas</i> (IVW, β = 0.06, <i>p</i> = 0.019), and <i>Lachnospira</i> (IVW, β = −0.18, <i>p</i> = 0.01) were suggestive of causal associations with Bioage acceleration, with the latter being protective. <i>Actinomyces</i> (IVW, β = 0.26, <i>p</i> = 0.0083), <i>Butyricimonas</i> (IVW, β = 0.21, <i>p</i> = 0.0184), and <i>Lachnospiraceae</i> (<i>FCS020 group</i>) (IVW, β = 0.24, <i>p</i> = 0.0194) were suggestive of causal associations with Phenoage acceleration. This Mendelian randomization study found that <i>Streptococcus</i> was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.https://www.mdpi.com/2076-2607/12/2/370biological agingaginggut microbiotamendelian randomization studyinstrumental variables |
| spellingShingle | Chenglin Ye Zhiqiang Li Chun Ye Li Yuan Kailang Wu Chengliang Zhu Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study Microorganisms biological aging aging gut microbiota mendelian randomization study instrumental variables |
| title | Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study |
| title_full | Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study |
| title_fullStr | Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study |
| title_full_unstemmed | Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study |
| title_short | Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study |
| title_sort | association between gut microbiota and biological aging a two sample mendelian randomization study |
| topic | biological aging aging gut microbiota mendelian randomization study instrumental variables |
| url | https://www.mdpi.com/2076-2607/12/2/370 |
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