Protofibrillar Amyloid Beta Modulation of Recombinant hCaV2.2 (N-Type) Voltage-Gated Channels

Protofibrillar Amyloid Beta Modulation of Recombinant hCaV2.2 (N-Type) Voltage-Gated Channels

Cav2.2 channels are key regulators of presynaptic Ca<sup>2+</sup> influx and their dysfunction and/or aberrant regulation has been implicated in many disease states; however, the nature of their involvement in Alzheimer’s disease (AD) is less clear. In this short communication, we show t...

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Bibliographic Details
Main Authors: Eleni Kaisis, Laura J. Thei, Gary J. Stephens, Mark L. Dallas
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceuticals
Subjects:
ion channel
amyloid beta
voltage-gated calcium channel
neurodegeneration
Alzheimer’s disease
Online Access:https://www.mdpi.com/1424-8247/15/12/1459

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