MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2

MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2

Abstract Background MAL (T-lymphocyte maturation-associated protein) is highly downregulated in most cancers, including cervical cancer (CaCx), attributable to promoter hypermethylation. Long noncoding RNA genes (lncGs) play pivotal roles in CaCx pathogenesis, by interacting with human papillomaviru...

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Bibliographic Details
Main Authors: Abarna Sinha, Abhisikta Ghosh, Arnab Ghosh, Sonia Mathai, Jaydip Bhaumik, Asima Mukhopadhyay, Arindam Maitra, Nidhan K. Biswas, Sharmila Sengupta
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Clinical Epigenetics
Subjects:
Antisense long noncoding RNA AC103563.8
Cervical cancer
EZH2-mediated H3K27me3 marks
HPV16-E7
MAL
Patient survival
Online Access:https://doi.org/10.1186/s13148-024-01651-9

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