Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position

New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd2(dba)3/DPPF/Cs2CO3/toluene combination.

Bibliographic Details
Main Authors: Haihong Huang, Dali Yin, Xiaojian Wang, Chun Li, Hao Zhang, Gang Zhang
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/16/8/6985/
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author Haihong Huang
Dali Yin
Xiaojian Wang
Chun Li
Hao Zhang
Gang Zhang
author_facet Haihong Huang
Dali Yin
Xiaojian Wang
Chun Li
Hao Zhang
Gang Zhang
author_sort Haihong Huang
collection DOAJ
description New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd2(dba)3/DPPF/Cs2CO3/toluene combination.
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spelling doaj.art-8fc9f75510494ff0ad59b8c291f9811b2022-12-22T01:42:38ZengMDPI AGMolecules1420-30492011-08-011686985699110.3390/molecules16086985Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N PositionHaihong HuangDali YinXiaojian WangChun LiHao ZhangGang ZhangNew riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd2(dba)3/DPPF/Cs2CO3/toluene combination.http://www.mdpi.com/1420-3049/16/8/6985/riminophenazineN-arylationpalladium catalyst
spellingShingle Haihong Huang
Dali Yin
Xiaojian Wang
Chun Li
Hao Zhang
Gang Zhang
Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position
Molecules
riminophenazine
N-arylation
palladium catalyst
title Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position
title_full Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position
title_fullStr Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position
title_full_unstemmed Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position
title_short Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position
title_sort synthesis of new riminophenazines with pyrimidine and pyrazine substitution at the 2 n position
topic riminophenazine
N-arylation
palladium catalyst
url http://www.mdpi.com/1420-3049/16/8/6985/
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