Study of microalbuminuria and its correlation with glycaemic status in type 2 diabetes mellitus
Background: It is well established that diabetic nephropathy is a dreaded complication of Type 2 diabetes mellitus. However in the early stages; also known as incipient nephropathy, it can be detected by the presence of microalbuminuria. If the patient is identified in the incipient nephropathy stag...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | MRIMS Journal of Health Sciences |
| Subjects: | |
| Online Access: | http://www.mrimsjournal.com/article.asp?issn=2321-7006;year=2016;volume=4;issue=4;spage=203;epage=207;aulast=Srjana;type=0 |
| Summary: | Background: It is well established that diabetic nephropathy is a dreaded complication of Type 2 diabetes mellitus. However in the early stages; also known as incipient nephropathy, it can be detected by the presence of microalbuminuria. If the patient is identified in the incipient nephropathy stage itself, effective control measures can be initiated to retard the progression to end stage renal disease.
Objective: To know the occurrence of microalbuminuria in patients with Type 2 diabetes mellitus and to correlate it with the glycaemic status of the patients.
Methods: This study was undertaken in NRI Medical College and General Hospital, Chinakakani, Guntur District, Andhra Pradesh from Nov. 2010 to August 2012. A total of one hundred randomly selected diabetic patients satisfying the inclusion criteria were selected for the study. All patients were evaluated in detail along with the testing for microalbuminuria with dipsticks (Micral) and their glycaemic status along with other required parameters.
Results: The overall occurrence of microalbuminuria in the test series was 38%. The occurrence of microalbuminuria showed a direct relationship with the poor glycemic status (p=0.053) and increasing duration of diabetes since diagnosis (p<0.001). An HbA1c value above 7% is associated with 50% or higher incidence of microalbuminuria (p=0.018). Patients with a body mass index of more than 25 kg/m2 have a significant increase in the incidence of microalbuminuria (p=0.027). The incidence of microalbuminuria is significantly associated with the presence of retinopathy (p=0.073), peripheral neuropathy (p=0.009), ischemic heart disease (p=0.011) and hypertension (p=0.001). Microalbuminuria is inversely associated with HDL (p= 0.089).
Conclusion: The occurrence of microalbuminuria in Type 2 diabetic patients in the study was quite high and more so in patients with poor glycemic control. |
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| ISSN: | 2321-7006 2321-7294 |