Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children

Abstract To identify and compare keratometric, corneal thickness, and elevation parameters and indices among healthy children, ocular allergy, and keratoconus using the OCULUS Pentacam Scheimpflug topography system. This study included healthy children, children with ocular allergy (OA) without kera...

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Main Authors: Matheus Ivan Schmitz Vieira, Alessandro Adad Jammal, Carlos Eduardo Leite Arieta, Monica Alves, Jose Paulo Cabral de Vasconcellos
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-03818-3
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author Matheus Ivan Schmitz Vieira
Alessandro Adad Jammal
Carlos Eduardo Leite Arieta
Monica Alves
Jose Paulo Cabral de Vasconcellos
author_facet Matheus Ivan Schmitz Vieira
Alessandro Adad Jammal
Carlos Eduardo Leite Arieta
Monica Alves
Jose Paulo Cabral de Vasconcellos
author_sort Matheus Ivan Schmitz Vieira
collection DOAJ
description Abstract To identify and compare keratometric, corneal thickness, and elevation parameters and indices among healthy children, ocular allergy, and keratoconus using the OCULUS Pentacam Scheimpflug topography system. This study included healthy children, children with ocular allergy (OA) without keratoconus, and children with keratoconus (KC). The study design consisted of a prospective evaluation and review of medical records from a Brazilian ophthalmology department. The exclusion criteria were inability to undergo the ocular exam, other ocular diseases, contact lens wear, and topographic corneal ectasia. The effect of each corneal parameter was evaluated using univariate and multivariate logistic regression models adjusted for sex and age, and ROC curves were used to assess the ability each variable to discriminate among groups. A total of 182 subjects were included: healthy children (n = 99), children with OA (n = 32), and children with KC (n = 51). Groups differed in terms of sex, with more males in the OA group (73.2%) and the KC group (67.7%) than in the control group (40.9%). All corneal parameters studied differed significantly between the control and KC groups, and between the OA and KC groups; they also differed significantly between the three groups in terms of astigmatism, q-value, CCT, TP, BAD-D, and ARTmax values. We present the first study to describe and compare corneal tomographic parameters in healthy children, OA, and KC. Keratometry indices, ACD, ARTmax, AETP, and PETP were found to be the most useful for differentiating between healthy and KC children. IBR registry number: CAAE 54921916.9.0000.5404.
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spelling doaj.art-8fcb07e8522443a7aa896aab44b14f272022-12-21T19:38:00ZengNature PortfolioScientific Reports2045-23222021-12-0111111010.1038/s41598-021-03818-3Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in childrenMatheus Ivan Schmitz Vieira0Alessandro Adad Jammal1Carlos Eduardo Leite Arieta2Monica Alves3Jose Paulo Cabral de Vasconcellos4Department of Ophthalmology and Otorhinolaryngology, School of Medical Sciences, University of CampinasDepartment of Ophthalmology and Otorhinolaryngology, School of Medical Sciences, University of CampinasDepartment of Ophthalmology and Otorhinolaryngology, School of Medical Sciences, University of CampinasDepartment of Ophthalmology and Otorhinolaryngology, School of Medical Sciences, University of CampinasDepartment of Ophthalmology and Otorhinolaryngology, School of Medical Sciences, University of CampinasAbstract To identify and compare keratometric, corneal thickness, and elevation parameters and indices among healthy children, ocular allergy, and keratoconus using the OCULUS Pentacam Scheimpflug topography system. This study included healthy children, children with ocular allergy (OA) without keratoconus, and children with keratoconus (KC). The study design consisted of a prospective evaluation and review of medical records from a Brazilian ophthalmology department. The exclusion criteria were inability to undergo the ocular exam, other ocular diseases, contact lens wear, and topographic corneal ectasia. The effect of each corneal parameter was evaluated using univariate and multivariate logistic regression models adjusted for sex and age, and ROC curves were used to assess the ability each variable to discriminate among groups. A total of 182 subjects were included: healthy children (n = 99), children with OA (n = 32), and children with KC (n = 51). Groups differed in terms of sex, with more males in the OA group (73.2%) and the KC group (67.7%) than in the control group (40.9%). All corneal parameters studied differed significantly between the control and KC groups, and between the OA and KC groups; they also differed significantly between the three groups in terms of astigmatism, q-value, CCT, TP, BAD-D, and ARTmax values. We present the first study to describe and compare corneal tomographic parameters in healthy children, OA, and KC. Keratometry indices, ACD, ARTmax, AETP, and PETP were found to be the most useful for differentiating between healthy and KC children. IBR registry number: CAAE 54921916.9.0000.5404.https://doi.org/10.1038/s41598-021-03818-3
spellingShingle Matheus Ivan Schmitz Vieira
Alessandro Adad Jammal
Carlos Eduardo Leite Arieta
Monica Alves
Jose Paulo Cabral de Vasconcellos
Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children
Scientific Reports
title Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children
title_full Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children
title_fullStr Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children
title_full_unstemmed Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children
title_short Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children
title_sort corneal scheimpflug topography values to distinguish between normal eyes ocular allergy and keratoconus in children
url https://doi.org/10.1038/s41598-021-03818-3
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