Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients.
Diabetes mellitus (DM) is the most common cause of end-stage renal disease and is an important risk factor for morbidity and mortality after dialysis. However, glycemic control among such patients is difficult to assess. The present study examined glycemic control parameters and observed glucose var...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3587617?pdf=render |
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| author | Szu-Ying Lee Yin-Cheng Chen I-Chieh Tsai Chung-Jen Yen Shu-Neng Chueh Hsueh-Fang Chuang Hon-Yen Wu Chih-Kang Chiang Hui-Teng Cheng Kuan-Yu Hung Jenq-Wen Huang |
| author_facet | Szu-Ying Lee Yin-Cheng Chen I-Chieh Tsai Chung-Jen Yen Shu-Neng Chueh Hsueh-Fang Chuang Hon-Yen Wu Chih-Kang Chiang Hui-Teng Cheng Kuan-Yu Hung Jenq-Wen Huang |
| author_sort | Szu-Ying Lee |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is the most common cause of end-stage renal disease and is an important risk factor for morbidity and mortality after dialysis. However, glycemic control among such patients is difficult to assess. The present study examined glycemic control parameters and observed glucose variation after refilling different kinds of fresh dialysate in peritoneal dialysis (PD) patients.A total of 25 DM PD patients were recruited, and continuous glucose monitoring system (CGMS) was applied to measure interstitial fluid (ISF) glucose levels at 5-min intervals for 3 days. Patients filled out diet and PD fluid exchange diaries. The records measured with CGMS were analyzed and correlated with other glycemic control parameters such as fructosamine, albumin-corrected fructosamine (AlbF), glycosylated hemoglobin (HbA1c), and glycated albumin levels.There were significant correlations between mean ISF glucose and fructosamine (r = 0.45, P<0.05), AlbF (r = 0.54, P<0.01), and HbA1c (r = 0.51, P<0.01). The ISF glucose levels in glucose-containing dialysate increased from approximately 7-8 mg/dL within 1 hour of exchange in contrast to icodextrin dialysate which kept ISF glucose levels unchanged.HbA1c and AlbF significantly correlated with the mean ISF glucose levels, indicating that they are reliable indices of glycemic control in DM PD patients. Icodextrin dialysate seems to have a favorable glycemic control effect when compared to the other glucose-containing dialysates. |
| first_indexed | 2024-04-13T22:57:46Z |
| format | Article |
| id | doaj.art-8fcb3caafb58477fb3d985e2e378f193 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T22:57:46Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8fcb3caafb58477fb3d985e2e378f1932022-12-22T02:25:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5776210.1371/journal.pone.0057762Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients.Szu-Ying LeeYin-Cheng ChenI-Chieh TsaiChung-Jen YenShu-Neng ChuehHsueh-Fang ChuangHon-Yen WuChih-Kang ChiangHui-Teng ChengKuan-Yu HungJenq-Wen HuangDiabetes mellitus (DM) is the most common cause of end-stage renal disease and is an important risk factor for morbidity and mortality after dialysis. However, glycemic control among such patients is difficult to assess. The present study examined glycemic control parameters and observed glucose variation after refilling different kinds of fresh dialysate in peritoneal dialysis (PD) patients.A total of 25 DM PD patients were recruited, and continuous glucose monitoring system (CGMS) was applied to measure interstitial fluid (ISF) glucose levels at 5-min intervals for 3 days. Patients filled out diet and PD fluid exchange diaries. The records measured with CGMS were analyzed and correlated with other glycemic control parameters such as fructosamine, albumin-corrected fructosamine (AlbF), glycosylated hemoglobin (HbA1c), and glycated albumin levels.There were significant correlations between mean ISF glucose and fructosamine (r = 0.45, P<0.05), AlbF (r = 0.54, P<0.01), and HbA1c (r = 0.51, P<0.01). The ISF glucose levels in glucose-containing dialysate increased from approximately 7-8 mg/dL within 1 hour of exchange in contrast to icodextrin dialysate which kept ISF glucose levels unchanged.HbA1c and AlbF significantly correlated with the mean ISF glucose levels, indicating that they are reliable indices of glycemic control in DM PD patients. Icodextrin dialysate seems to have a favorable glycemic control effect when compared to the other glucose-containing dialysates.http://europepmc.org/articles/PMC3587617?pdf=render |
| spellingShingle | Szu-Ying Lee Yin-Cheng Chen I-Chieh Tsai Chung-Jen Yen Shu-Neng Chueh Hsueh-Fang Chuang Hon-Yen Wu Chih-Kang Chiang Hui-Teng Cheng Kuan-Yu Hung Jenq-Wen Huang Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients. PLoS ONE |
| title | Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients. |
| title_full | Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients. |
| title_fullStr | Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients. |
| title_full_unstemmed | Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients. |
| title_short | Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients. |
| title_sort | glycosylated hemoglobin and albumin corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients |
| url | http://europepmc.org/articles/PMC3587617?pdf=render |
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