Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga

The prevalence of obesity and atopic disease in children, especially at school age increased in the last decade. Diseases mediated by IgE and atopy were influenced by genetic and environmental factors. Leptin resistance in obesity is associated with stimulation of TH 2 which affects the production o...

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Bibliographic Details
Main Authors: Budi Setiabudiawan, Reni Ghrahani, Gartika Sapartini, Putria Rayani, Citra Amelinda
Format: Article
Language:English
Published: Universitas Padjajaran 2013-06-01
Series:Majalah Kedokteran Bandung
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Online Access:http://journal.fk.unpad.ac.id/index.php/mkb/article/view/kadar%20Ige
Description
Summary:The prevalence of obesity and atopic disease in children, especially at school age increased in the last decade. Diseases mediated by IgE and atopy were influenced by genetic and environmental factors. Leptin resistance in obesity is associated with stimulation of TH 2 which affects the production of IgE. The purpose of this study was to determine the relationship of total IgE levels with obesity in children with or without family history of atopic disease. A cross-sectional study was conducted in the period April-September 2010, which involved 160 children aged 6–11 years at several elementary schools in Bandung. There are 4 groups: group 1: obese with family history of atopic disease, 2: normal nutrition with family history of atopic disease, 3: obese without family history of atopic disease, 4: normal nutrition without family history of atopic disease. Examination of total IgE levels were done by ECLIA method. Significance categorical data were tested by Chi-Square test, based on p <0.05. High total IgE levels in each group, respectively 30 (83%), 24 (60%), 21 (54%), and 11 (28%) children (p<0.001). In the group with family history of atopic disease, total IgE levels in obese children were higher [30 children (83%)] compared with normal nutrition [24 children (60%)] (p=0.025). In the group without family history of atopic disease, high total IgE levels in obese children [21 children (54%)] were higher than the normal nutrition [11 children (28%)] (p = 0.017). Inferred high total IgE levels more in obese children compared with normal nutrition with and without a history of atopic disease in the family
ISSN:0126-074X
2338-6223