Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga
The prevalence of obesity and atopic disease in children, especially at school age increased in the last decade. Diseases mediated by IgE and atopy were influenced by genetic and environmental factors. Leptin resistance in obesity is associated with stimulation of TH 2 which affects the production o...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Padjajaran
2013-06-01
|
| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/kadar%20Ige |
| _version_ | 1818427861304868864 |
|---|---|
| author | Budi Setiabudiawan Reni Ghrahani Gartika Sapartini Putria Rayani Citra Amelinda |
| author_facet | Budi Setiabudiawan Reni Ghrahani Gartika Sapartini Putria Rayani Citra Amelinda |
| author_sort | Budi Setiabudiawan |
| collection | DOAJ |
| description | The prevalence of obesity and atopic disease in children, especially at school age increased in the last decade. Diseases mediated by IgE and atopy were influenced by genetic and environmental factors. Leptin resistance in obesity is associated with stimulation of TH 2 which affects the production of IgE. The purpose of this study was to determine the relationship of total IgE levels with obesity in children with or without family history of atopic disease. A cross-sectional study was conducted in the period April-September 2010, which involved 160 children aged 6–11 years at several elementary schools in Bandung. There are 4 groups: group 1: obese with family history of atopic disease, 2: normal nutrition with family history of atopic disease, 3: obese without family history of atopic disease, 4: normal nutrition without family history of atopic disease. Examination of total IgE levels were done by ECLIA method. Significance categorical data were tested by Chi-Square test, based on p <0.05. High total IgE levels in each group, respectively 30 (83%), 24 (60%), 21 (54%), and 11 (28%) children (p<0.001). In the group with family history of atopic disease, total IgE levels in obese children were higher [30 children (83%)] compared with normal nutrition [24 children (60%)] (p=0.025). In the group without family history of atopic disease, high total IgE levels in obese children [21 children (54%)] were higher than the normal nutrition [11 children (28%)] (p = 0.017). Inferred high total IgE levels more in obese children compared with normal nutrition with and without a history of atopic disease in the family |
| first_indexed | 2024-12-14T14:52:27Z |
| format | Article |
| id | doaj.art-8fcc2501305b4790bfb154a9030e320b |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-14T14:52:27Z |
| publishDate | 2013-06-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-8fcc2501305b4790bfb154a9030e320b2022-12-21T22:57:05ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232013-06-0145213013410.15395/mkb.v45n2.87Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam KeluargaBudi Setiabudiawan0Reni Ghrahani1Gartika Sapartini2Putria Rayani3 Citra Amelinda4Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. HasanDepartemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. HasanDepartemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. HasanDepartemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. HasanThe prevalence of obesity and atopic disease in children, especially at school age increased in the last decade. Diseases mediated by IgE and atopy were influenced by genetic and environmental factors. Leptin resistance in obesity is associated with stimulation of TH 2 which affects the production of IgE. The purpose of this study was to determine the relationship of total IgE levels with obesity in children with or without family history of atopic disease. A cross-sectional study was conducted in the period April-September 2010, which involved 160 children aged 6–11 years at several elementary schools in Bandung. There are 4 groups: group 1: obese with family history of atopic disease, 2: normal nutrition with family history of atopic disease, 3: obese without family history of atopic disease, 4: normal nutrition without family history of atopic disease. Examination of total IgE levels were done by ECLIA method. Significance categorical data were tested by Chi-Square test, based on p <0.05. High total IgE levels in each group, respectively 30 (83%), 24 (60%), 21 (54%), and 11 (28%) children (p<0.001). In the group with family history of atopic disease, total IgE levels in obese children were higher [30 children (83%)] compared with normal nutrition [24 children (60%)] (p=0.025). In the group without family history of atopic disease, high total IgE levels in obese children [21 children (54%)] were higher than the normal nutrition [11 children (28%)] (p = 0.017). Inferred high total IgE levels more in obese children compared with normal nutrition with and without a history of atopic disease in the familyhttp://journal.fk.unpad.ac.id/index.php/mkb/article/view/kadar%20IgeAtopyfamily historyobesitytotal IgE level |
| spellingShingle | Budi Setiabudiawan Reni Ghrahani Gartika Sapartini Putria Rayani Citra Amelinda Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga Majalah Kedokteran Bandung Atopy family history obesity total IgE level |
| title | Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga |
| title_full | Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga |
| title_fullStr | Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga |
| title_full_unstemmed | Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga |
| title_short | Kadar IgE Total pada Anak Obesitas Dengan atau Tanpa Riwayat Penyakit Atopik dalam Keluarga |
| title_sort | kadar ige total pada anak obesitas dengan atau tanpa riwayat penyakit atopik dalam keluarga |
| topic | Atopy family history obesity total IgE level |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/kadar%20Ige |
| work_keys_str_mv | AT budisetiabudiawan kadarigetotalpadaanakobesitasdenganatautanpariwayatpenyakitatopikdalamkeluarga AT renighrahani kadarigetotalpadaanakobesitasdenganatautanpariwayatpenyakitatopikdalamkeluarga AT gartikasapartini kadarigetotalpadaanakobesitasdenganatautanpariwayatpenyakitatopikdalamkeluarga AT putriarayani kadarigetotalpadaanakobesitasdenganatautanpariwayatpenyakitatopikdalamkeluarga AT citraamelinda kadarigetotalpadaanakobesitasdenganatautanpariwayatpenyakitatopikdalamkeluarga |