Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS
Veterinary antibiotics have become a major concern due to potential environmental effects. This study presents an investigation of the exposure and environmental effects of the veterinary medicinal product in powder form, administered in the drinking water of piglets, chickens and turkeys, containin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/17/6227 |
| _version_ | 1827728048301015040 |
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| author | Viviana Carmen Ciucă Victor Viorel Safta Carmen Otilia Rusănescu Gigel Paraschiv György Deák Mihaela Ilie Sorin Cănănău |
| author_facet | Viviana Carmen Ciucă Victor Viorel Safta Carmen Otilia Rusănescu Gigel Paraschiv György Deák Mihaela Ilie Sorin Cănănău |
| author_sort | Viviana Carmen Ciucă |
| collection | DOAJ |
| description | Veterinary antibiotics have become a major concern due to potential environmental effects. This study presents an investigation of the exposure and environmental effects of the veterinary medicinal product in powder form, administered in the drinking water of piglets, chickens and turkeys, containing 250 mg/g penicillin G (benzylpenicillin potassium), performed according to the European Medicines Agency (EMEA) guideline and the results obtained by an analytical method based on online solid-phase extraction, ultra-high performance liquid chromatography coupled to a triple quadrupole mass spectrometer (SPE-online-UHPLC-MS/MS). The study presents the determination of the environmental risk and through an original, interactive, fast software method, created on the basis of a proprietary calculation algorithm that goes through all the prescriptions and recommendations of the EMEA guide. The results demonstrated that the concentration value for penicillin G determined in surface water by SPE-online-UHPLC-MS/MS is much lower than that predicted by calculation (predictable concentration in surface water, PECsurface water = 37.66 µg/L and the concentration SPE-online-UHPLC-MS/MS = 0.032 µg/L). Both results lead to a sub-unit risk quotient (R) indicating that the treatment carried out with the considered veterinary product does not present any risk to the environment. |
| first_indexed | 2024-03-10T23:17:32Z |
| format | Article |
| id | doaj.art-8fcc285184984b8e864c925e2c73a610 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T23:17:32Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8fcc285184984b8e864c925e2c73a6102023-11-19T08:33:04ZengMDPI AGMolecules1420-30492023-08-012817622710.3390/molecules28176227Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MSViviana Carmen Ciucă0Victor Viorel Safta1Carmen Otilia Rusănescu2Gigel Paraschiv3György Deák4Mihaela Ilie5Sorin Cănănău6Faculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, RomaniaFaculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, RomaniaFaculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, RomaniaFaculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, RomaniaNational Institute for Research and Development in Environmental Protection, 294 Spl. Independentei, District 6, 060031 Bucharest, RomaniaNational Institute for Research and Development in Environmental Protection, 294 Spl. Independentei, District 6, 060031 Bucharest, RomaniaFaculty of Mechanical and Mechatronic Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, RomaniaVeterinary antibiotics have become a major concern due to potential environmental effects. This study presents an investigation of the exposure and environmental effects of the veterinary medicinal product in powder form, administered in the drinking water of piglets, chickens and turkeys, containing 250 mg/g penicillin G (benzylpenicillin potassium), performed according to the European Medicines Agency (EMEA) guideline and the results obtained by an analytical method based on online solid-phase extraction, ultra-high performance liquid chromatography coupled to a triple quadrupole mass spectrometer (SPE-online-UHPLC-MS/MS). The study presents the determination of the environmental risk and through an original, interactive, fast software method, created on the basis of a proprietary calculation algorithm that goes through all the prescriptions and recommendations of the EMEA guide. The results demonstrated that the concentration value for penicillin G determined in surface water by SPE-online-UHPLC-MS/MS is much lower than that predicted by calculation (predictable concentration in surface water, PECsurface water = 37.66 µg/L and the concentration SPE-online-UHPLC-MS/MS = 0.032 µg/L). Both results lead to a sub-unit risk quotient (R) indicating that the treatment carried out with the considered veterinary product does not present any risk to the environment.https://www.mdpi.com/1420-3049/28/17/6227Penicillin Grisk assessmentsoftware methodSPE-online-UHPLC-MS/MS |
| spellingShingle | Viviana Carmen Ciucă Victor Viorel Safta Carmen Otilia Rusănescu Gigel Paraschiv György Deák Mihaela Ilie Sorin Cănănău Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS Molecules Penicillin G risk assessment software method SPE-online-UHPLC-MS/MS |
| title | Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS |
| title_full | Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS |
| title_fullStr | Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS |
| title_full_unstemmed | Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS |
| title_short | Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS |
| title_sort | rapid environmental impact assessment of penicillin g in a veterinary product using an original software method and monitoring by spe online uhplc ms ms |
| topic | Penicillin G risk assessment software method SPE-online-UHPLC-MS/MS |
| url | https://www.mdpi.com/1420-3049/28/17/6227 |
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