HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor program
Pediatric, adolescent and young adult patients undergoing cancer treatment and/or hematopoietic stem cell transplant are at increased risk for developing a secondary human papillomavirus (HPV)-associated malignancy. The objective of this study was to determine HPV vaccination coverage among individu...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Preventive Medicine Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335522002790 |
| _version_ | 1818020987814281216 |
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| author | Lauren Thomaier Danielle A. Aase Rachel I. Vogel Helen M. Parsons Karim T. Sadak Deanna Teoh |
| author_facet | Lauren Thomaier Danielle A. Aase Rachel I. Vogel Helen M. Parsons Karim T. Sadak Deanna Teoh |
| author_sort | Lauren Thomaier |
| collection | DOAJ |
| description | Pediatric, adolescent and young adult patients undergoing cancer treatment and/or hematopoietic stem cell transplant are at increased risk for developing a secondary human papillomavirus (HPV)-associated malignancy. The objective of this study was to determine HPV vaccination coverage among individuals participating in a childhood cancer survivor program (CCSP). A retrospective cohort study was conducted among CCSP patients age 11–26 years attending a CCSP visit between 2014 and 2019. Survivors were age-, sex-, and race-matched 1:2 with controls without cancer. Data were abstracted from the electronic health record and state-based vaccination registry. Analysis was limited to Minnesota residents to minimize missing vaccination data. Survivorship care plans (SCPs) were reviewed for vaccine recommendations.592 patients were included in the analyses (200 CCSP patients; 392 controls). By study design, mean age (18.4 years), race (72 % white), and sex (49 % female) were similar in the two groups. Among CCSP patients 22 % resided in a rural area compared to 3.8 % of controls. Vaccination coverage among CCSP patients was not statistically significantly different from controls [60.0 % vs 66.3 %, OR = 0.82, 95 % CI: (0.55, 1.23), p = 0.35]. Completion of 3 doses was not different between groups even though 3 doses is recommended for all CCSP patients regardless of age at initiation (28.5 % vs 30.1 %, p = 0.09). Only 8.0 % of SCPs recommended HPV vaccination.Although patients participating in a CCSP did not have significantly different HPV vaccination coverage compared to controls, HPV vaccination initiation and 3-dose series completion are still suboptimal in a patient population at high-risk of a secondary HPV-associated cancer. |
| first_indexed | 2024-04-14T08:12:59Z |
| format | Article |
| id | doaj.art-8fcd64fc4c004b11bc8d971ba2d29571 |
| institution | Directory Open Access Journal |
| issn | 2211-3355 |
| language | English |
| last_indexed | 2024-04-14T08:12:59Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj.art-8fcd64fc4c004b11bc8d971ba2d295712022-12-22T02:04:30ZengElsevierPreventive Medicine Reports2211-33552022-10-0129101972HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor programLauren Thomaier0Danielle A. Aase1Rachel I. Vogel2Helen M. Parsons3Karim T. Sadak4Deanna Teoh5Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, United StatesUniversity of Minnesota Medical School, Minneapolis, MN, United StatesDivision of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, United StatesDivision of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, United StatesDivision of Hematology/Oncology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, United StatesDivision of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, United States; Corresponding author.Pediatric, adolescent and young adult patients undergoing cancer treatment and/or hematopoietic stem cell transplant are at increased risk for developing a secondary human papillomavirus (HPV)-associated malignancy. The objective of this study was to determine HPV vaccination coverage among individuals participating in a childhood cancer survivor program (CCSP). A retrospective cohort study was conducted among CCSP patients age 11–26 years attending a CCSP visit between 2014 and 2019. Survivors were age-, sex-, and race-matched 1:2 with controls without cancer. Data were abstracted from the electronic health record and state-based vaccination registry. Analysis was limited to Minnesota residents to minimize missing vaccination data. Survivorship care plans (SCPs) were reviewed for vaccine recommendations.592 patients were included in the analyses (200 CCSP patients; 392 controls). By study design, mean age (18.4 years), race (72 % white), and sex (49 % female) were similar in the two groups. Among CCSP patients 22 % resided in a rural area compared to 3.8 % of controls. Vaccination coverage among CCSP patients was not statistically significantly different from controls [60.0 % vs 66.3 %, OR = 0.82, 95 % CI: (0.55, 1.23), p = 0.35]. Completion of 3 doses was not different between groups even though 3 doses is recommended for all CCSP patients regardless of age at initiation (28.5 % vs 30.1 %, p = 0.09). Only 8.0 % of SCPs recommended HPV vaccination.Although patients participating in a CCSP did not have significantly different HPV vaccination coverage compared to controls, HPV vaccination initiation and 3-dose series completion are still suboptimal in a patient population at high-risk of a secondary HPV-associated cancer.http://www.sciencedirect.com/science/article/pii/S2211335522002790HPV vaccinationPediatricAdolescentYoung adult cancer survivorsSurvivorshipSecondary cancer prevention |
| spellingShingle | Lauren Thomaier Danielle A. Aase Rachel I. Vogel Helen M. Parsons Karim T. Sadak Deanna Teoh HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor program Preventive Medicine Reports HPV vaccination Pediatric Adolescent Young adult cancer survivors Survivorship Secondary cancer prevention |
| title | HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor program |
| title_full | HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor program |
| title_fullStr | HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor program |
| title_full_unstemmed | HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor program |
| title_short | HPV vaccination coverage for pediatric, adolescent and young adult patients receiving care in a childhood cancer survivor program |
| title_sort | hpv vaccination coverage for pediatric adolescent and young adult patients receiving care in a childhood cancer survivor program |
| topic | HPV vaccination Pediatric Adolescent Young adult cancer survivors Survivorship Secondary cancer prevention |
| url | http://www.sciencedirect.com/science/article/pii/S2211335522002790 |
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