In Vivo Optofluidic Switch for Controlling Blood Microflow
Abstract Control of blood microflow is crucial for the prevention and therapy of blood disorders, such as cardiovascular diseases and their complications. Conventional control strategies generally implant exogenous synthetic materials into blood vessels as labeling markers or actuating sources, whic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-07-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202001414 |
| _version_ | 1818506481884987392 |
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| author | Xiaoshuai Liu Qing Gao Yao Zhang Yuchao Li Baojun Li |
| author_facet | Xiaoshuai Liu Qing Gao Yao Zhang Yuchao Li Baojun Li |
| author_sort | Xiaoshuai Liu |
| collection | DOAJ |
| description | Abstract Control of blood microflow is crucial for the prevention and therapy of blood disorders, such as cardiovascular diseases and their complications. Conventional control strategies generally implant exogenous synthetic materials into blood vessels as labeling markers or actuating sources, which are invasive and incompatible with biological systems. Here, a label‐free, noninvasive, and biocompatible device constructed from natural red blood cells (RBCs) for controlling blood microflow in vivo is reported. The RBCs, optically manipulated, arranged, and rotated using scanning optical tweezers, can function as an optofluidic switch for targeted switching, directional enrichment, dynamic redirecting, and rotary actuation of blood microflow inside zebrafish. The regulation precision of the switch is determined to be at the single‐cell level, and the response time is measured as ≈200 ms using a streamline tracking method. This in vivo optofluidic switch may provide a biofriendly device for exploring blood microenvironments in a noncontact and noninvasive manner. |
| first_indexed | 2024-12-10T22:05:11Z |
| format | Article |
| id | doaj.art-8fd176a330cf4a6192aff2d7c685976b |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T22:05:11Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-8fd176a330cf4a6192aff2d7c685976b2022-12-22T01:31:46ZengWileyAdvanced Science2198-38442020-07-01714n/an/a10.1002/advs.202001414In Vivo Optofluidic Switch for Controlling Blood MicroflowXiaoshuai Liu0Qing Gao1Yao Zhang2Yuchao Li3Baojun Li4Institute of Nanophotonics Jinan University Guangzhou 511‐443 ChinaInstitute of Nanophotonics Jinan University Guangzhou 511‐443 ChinaInstitute of Nanophotonics Jinan University Guangzhou 511‐443 ChinaInstitute of Nanophotonics Jinan University Guangzhou 511‐443 ChinaInstitute of Nanophotonics Jinan University Guangzhou 511‐443 ChinaAbstract Control of blood microflow is crucial for the prevention and therapy of blood disorders, such as cardiovascular diseases and their complications. Conventional control strategies generally implant exogenous synthetic materials into blood vessels as labeling markers or actuating sources, which are invasive and incompatible with biological systems. Here, a label‐free, noninvasive, and biocompatible device constructed from natural red blood cells (RBCs) for controlling blood microflow in vivo is reported. The RBCs, optically manipulated, arranged, and rotated using scanning optical tweezers, can function as an optofluidic switch for targeted switching, directional enrichment, dynamic redirecting, and rotary actuation of blood microflow inside zebrafish. The regulation precision of the switch is determined to be at the single‐cell level, and the response time is measured as ≈200 ms using a streamline tracking method. This in vivo optofluidic switch may provide a biofriendly device for exploring blood microenvironments in a noncontact and noninvasive manner.https://doi.org/10.1002/advs.202001414blood microflowoptical tweezersoptofluidic manipulationred blood cells |
| spellingShingle | Xiaoshuai Liu Qing Gao Yao Zhang Yuchao Li Baojun Li In Vivo Optofluidic Switch for Controlling Blood Microflow Advanced Science blood microflow optical tweezers optofluidic manipulation red blood cells |
| title | In Vivo Optofluidic Switch for Controlling Blood Microflow |
| title_full | In Vivo Optofluidic Switch for Controlling Blood Microflow |
| title_fullStr | In Vivo Optofluidic Switch for Controlling Blood Microflow |
| title_full_unstemmed | In Vivo Optofluidic Switch for Controlling Blood Microflow |
| title_short | In Vivo Optofluidic Switch for Controlling Blood Microflow |
| title_sort | in vivo optofluidic switch for controlling blood microflow |
| topic | blood microflow optical tweezers optofluidic manipulation red blood cells |
| url | https://doi.org/10.1002/advs.202001414 |
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