Cetirizine a histamine H1 receptor antagonist improves viral myocarditis
<p>Abstract</p> <p>Background</p> <p>We showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study, we investigated the effect of cetirizine, a selective H1 receptor antagon...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-08-01
|
| Series: | Journal of Inflammation |
| Online Access: | http://www.journal-inflammation.com/content/7/1/39 |
| _version_ | 1811252127819890688 |
|---|---|
| author | Yamamoto Kanjo Matsumori Akira Shimada Miho |
| author_facet | Yamamoto Kanjo Matsumori Akira Shimada Miho |
| author_sort | Yamamoto Kanjo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>We showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study, we investigated the effect of cetirizine, a selective H1 receptor antagonist, on experimental viral myocarditis induced by encephalomyocarditis (EMC) virus.</p> <p>Methods</p> <p>Four-week-old inbred male DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units (pfu) of the EMC virus. Cetirizine was administered orally at a dose of 1 or 10 mg/kg per day for the survival study, and 1 mg/kg for the histologic and gene expression studies, beginning on the day of viral inoculation.</p> <p>Results</p> <p>Cetirizine improved survival dose dependently. Heart weight to body weight ratio was significantly decreased in mice treated with cetirizine. The area of myocardial necrosis was significantly smaller in the hearts of mice treated with cetirizine compared with controls. Gene expressions of tumor necrosis factor, interleukin 6, and metalloproteinase 2 were significantly suppressed in the hearts of mice treated with cetirizine.</p> <p>Conclusion</p> <p>These results suggest that cetirizine exerts its beneficial effects on viral myocarditis by suppressing expression of pro-inflammatory cytokines, genes related to cardiac remodeling in the hearts of mice.</p> |
| first_indexed | 2024-04-12T16:30:14Z |
| format | Article |
| id | doaj.art-8fd55996aa4a424fb87d0fd45eceeecd |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-04-12T16:30:14Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-8fd55996aa4a424fb87d0fd45eceeecd2022-12-22T03:25:10ZengBMCJournal of Inflammation1476-92552010-08-01713910.1186/1476-9255-7-39Cetirizine a histamine H1 receptor antagonist improves viral myocarditisYamamoto KanjoMatsumori AkiraShimada Miho<p>Abstract</p> <p>Background</p> <p>We showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study, we investigated the effect of cetirizine, a selective H1 receptor antagonist, on experimental viral myocarditis induced by encephalomyocarditis (EMC) virus.</p> <p>Methods</p> <p>Four-week-old inbred male DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units (pfu) of the EMC virus. Cetirizine was administered orally at a dose of 1 or 10 mg/kg per day for the survival study, and 1 mg/kg for the histologic and gene expression studies, beginning on the day of viral inoculation.</p> <p>Results</p> <p>Cetirizine improved survival dose dependently. Heart weight to body weight ratio was significantly decreased in mice treated with cetirizine. The area of myocardial necrosis was significantly smaller in the hearts of mice treated with cetirizine compared with controls. Gene expressions of tumor necrosis factor, interleukin 6, and metalloproteinase 2 were significantly suppressed in the hearts of mice treated with cetirizine.</p> <p>Conclusion</p> <p>These results suggest that cetirizine exerts its beneficial effects on viral myocarditis by suppressing expression of pro-inflammatory cytokines, genes related to cardiac remodeling in the hearts of mice.</p>http://www.journal-inflammation.com/content/7/1/39 |
| spellingShingle | Yamamoto Kanjo Matsumori Akira Shimada Miho Cetirizine a histamine H1 receptor antagonist improves viral myocarditis Journal of Inflammation |
| title | Cetirizine a histamine H1 receptor antagonist improves viral myocarditis |
| title_full | Cetirizine a histamine H1 receptor antagonist improves viral myocarditis |
| title_fullStr | Cetirizine a histamine H1 receptor antagonist improves viral myocarditis |
| title_full_unstemmed | Cetirizine a histamine H1 receptor antagonist improves viral myocarditis |
| title_short | Cetirizine a histamine H1 receptor antagonist improves viral myocarditis |
| title_sort | cetirizine a histamine h1 receptor antagonist improves viral myocarditis |
| url | http://www.journal-inflammation.com/content/7/1/39 |
| work_keys_str_mv | AT yamamotokanjo cetirizineahistamineh1receptorantagonistimprovesviralmyocarditis AT matsumoriakira cetirizineahistamineh1receptorantagonistimprovesviralmyocarditis AT shimadamiho cetirizineahistamineh1receptorantagonistimprovesviralmyocarditis |