Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection
Summary: Little is known about the persistence of human milk anti-SARS-CoV-2 antibodies after 2nd and 3rd vaccine doses and infection following 3rd dose. In this study, human milk, saliva, and blood samples were collected from 33 lactating individuals before and after vaccination and infection. Anti...
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Format: | Article |
Language: | English |
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Elsevier
2023-10-01
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Series: | iScience |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223018448 |
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author | Yarden Golan Mikias Ilala Lin Li Caryl Gay Soumya Hunagund Christine Y. Lin Arianna G. Cassidy Unurzul Jigmeddagva Yusuke Matsui Nida Ozarslan Ifeyinwa V. Asiodu Nadav Ahituv Valerie J. Flaherman Stephanie L. Gaw Mary Prahl |
author_facet | Yarden Golan Mikias Ilala Lin Li Caryl Gay Soumya Hunagund Christine Y. Lin Arianna G. Cassidy Unurzul Jigmeddagva Yusuke Matsui Nida Ozarslan Ifeyinwa V. Asiodu Nadav Ahituv Valerie J. Flaherman Stephanie L. Gaw Mary Prahl |
author_sort | Yarden Golan |
collection | DOAJ |
description | Summary: Little is known about the persistence of human milk anti-SARS-CoV-2 antibodies after 2nd and 3rd vaccine doses and infection following 3rd dose. In this study, human milk, saliva, and blood samples were collected from 33 lactating individuals before and after vaccination and infection. Antibody levels were measured using ELISA and symptoms were assessed using questionnaires. We found that after vaccination, milk anti-SARS-CoV-2 antibodies persisted for up to 8 months. In addition, distinct patterns of human milk IgA and IgG production and higher milk RBD-blocking activity was observed after infection compared to 3-dose vaccination. Infected mothers reported more symptoms than vaccinated mothers. We examined the persistence of milk antibodies in infant saliva after breastfeeding and found that IgA was more abundant compared to IgG. Our results emphasize the importance of improving the secretion of IgA antibodies to human milk after vaccination to improve the protection of breastfeeding infants. |
first_indexed | 2024-03-11T15:23:16Z |
format | Article |
id | doaj.art-8fd57b0a0d0047ceb54183623755eff6 |
institution | Directory Open Access Journal |
issn | 2589-0042 |
language | English |
last_indexed | 2024-03-11T15:23:16Z |
publishDate | 2023-10-01 |
publisher | Elsevier |
record_format | Article |
series | iScience |
spelling | doaj.art-8fd57b0a0d0047ceb54183623755eff62023-10-28T05:08:21ZengElsevieriScience2589-00422023-10-012610107767Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protectionYarden Golan0Mikias Ilala1Lin Li2Caryl Gay3Soumya Hunagund4Christine Y. Lin5Arianna G. Cassidy6Unurzul Jigmeddagva7Yusuke Matsui8Nida Ozarslan9Ifeyinwa V. Asiodu10Nadav Ahituv11Valerie J. Flaherman12Stephanie L. Gaw13Mary Prahl14Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USADepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USADivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USADepartment of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA, USADivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USADivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USADivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USADivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USAGladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USADivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USADepartment of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA, USADepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USADepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USADivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA; Corresponding authorDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA; Division of Pediatric Infectious Diseases and Global Health, University of California, San Francisco, San Francisco, CA, USA; Corresponding authorSummary: Little is known about the persistence of human milk anti-SARS-CoV-2 antibodies after 2nd and 3rd vaccine doses and infection following 3rd dose. In this study, human milk, saliva, and blood samples were collected from 33 lactating individuals before and after vaccination and infection. Antibody levels were measured using ELISA and symptoms were assessed using questionnaires. We found that after vaccination, milk anti-SARS-CoV-2 antibodies persisted for up to 8 months. In addition, distinct patterns of human milk IgA and IgG production and higher milk RBD-blocking activity was observed after infection compared to 3-dose vaccination. Infected mothers reported more symptoms than vaccinated mothers. We examined the persistence of milk antibodies in infant saliva after breastfeeding and found that IgA was more abundant compared to IgG. Our results emphasize the importance of improving the secretion of IgA antibodies to human milk after vaccination to improve the protection of breastfeeding infants.http://www.sciencedirect.com/science/article/pii/S2589004223018448Health sciencesPediatricsImmunologyVirology |
spellingShingle | Yarden Golan Mikias Ilala Lin Li Caryl Gay Soumya Hunagund Christine Y. Lin Arianna G. Cassidy Unurzul Jigmeddagva Yusuke Matsui Nida Ozarslan Ifeyinwa V. Asiodu Nadav Ahituv Valerie J. Flaherman Stephanie L. Gaw Mary Prahl Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection iScience Health sciences Pediatrics Immunology Virology |
title | Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection |
title_full | Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection |
title_fullStr | Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection |
title_full_unstemmed | Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection |
title_short | Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection |
title_sort | milk antibody response after 3rd covid 19 vaccine and sars cov 2 infection and implications for infant protection |
topic | Health sciences Pediatrics Immunology Virology |
url | http://www.sciencedirect.com/science/article/pii/S2589004223018448 |
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