JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21. However, the clinical effects of IFN hyperactivi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier 2020-11-01
Schriftenreihe:Cell Reports
Schlagworte:
Down syndrome
trisomy 21
interferon
cytokine storm
JAK inhibitors
autoimmunity
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2211124720313966

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http://www.sciencedirect.com/science/article/pii/S2211124720313966

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