JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21. However, the clinical effects of IFN hyperactivi...

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מידע ביבליוגרפי
Main Authors:	Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan
פורמט:	Article
שפה:	English
יצא לאור:	Elsevier 2020-11-01
סדרה:	Cell Reports
נושאים:	Down syndrome trisomy 21 interferon cytokine storm JAK inhibitors autoimmunity
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2211124720313966

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http://www.sciencedirect.com/science/article/pii/S2211124720313966

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

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