JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21. However, the clinical effects of IFN hyperactivi...

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書誌詳細
主要な著者: Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan
フォーマット: 論文
言語:English
出版事項: Elsevier 2020-11-01
シリーズ:Cell Reports
主題:
Down syndrome
trisomy 21
interferon
cytokine storm
JAK inhibitors
autoimmunity
オンライン･アクセス:http://www.sciencedirect.com/science/article/pii/S2211124720313966

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http://www.sciencedirect.com/science/article/pii/S2211124720313966

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