JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21. However, the clinical effects of IFN hyperactivi...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Elsevier 2020-11-01
Цуврал:Cell Reports
Нөхцлүүд:
Down syndrome
trisomy 21
interferon
cytokine storm
JAK inhibitors
autoimmunity
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S2211124720313966

Интернэт

http://www.sciencedirect.com/science/article/pii/S2211124720313966

Ижил төстэй зүйлс