Clinicopathological characteristics and management of extramedullary hematopoiesis: A review
Extramedullary hematopoiesis (EMH) is a rare entity most often associated with primary myelofibrosis, chronic myeloproliferative neoplasms, chronic hemolytic states, such as thalassemia, sickle cell anemia and certain solid tumors. Various theories have been postulated as the mechanism for occurrenc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Pediatric Hematology Oncology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468124522005137 |
| _version_ | 1797975194864713728 |
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| author | Sweety Gupta Ajay S. Krishnan Jyoti Singh Amit Gupta Manoj Gupta |
| author_facet | Sweety Gupta Ajay S. Krishnan Jyoti Singh Amit Gupta Manoj Gupta |
| author_sort | Sweety Gupta |
| collection | DOAJ |
| description | Extramedullary hematopoiesis (EMH) is a rare entity most often associated with primary myelofibrosis, chronic myeloproliferative neoplasms, chronic hemolytic states, such as thalassemia, sickle cell anemia and certain solid tumors. Various theories have been postulated as the mechanism for occurrence of EMH. Iron deposition and/or fatty infiltration along with increased density of liver and spleen may be observed on imaging. Also, organs may show diffuse involvement or mass like foci of hematopoiesis on imaging. Treatment includes transfusion, surgery, hydroxyurea and radiation. In this review we narrate the clinicopathological features, radiological imaging and treatment strategies of non hepatosplenic Extramedullary hematopoiesis. |
| first_indexed | 2024-04-11T04:31:38Z |
| format | Article |
| id | doaj.art-8fd87e03d9244fc680d9f7f9e3146049 |
| institution | Directory Open Access Journal |
| issn | 2468-1245 |
| language | English |
| last_indexed | 2024-04-11T04:31:38Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj.art-8fd87e03d9244fc680d9f7f9e31460492022-12-29T04:13:46ZengElsevierPediatric Hematology Oncology Journal2468-12452022-12-0174182186Clinicopathological characteristics and management of extramedullary hematopoiesis: A reviewSweety Gupta0Ajay S. Krishnan1Jyoti Singh2Amit Gupta3Manoj Gupta4Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, India; Corresponding author. Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, 249203, India.Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, IndiaDepartment of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, IndiaProfessor Department of Surgery, All India Institute of Medical Sciences, Rishikesh, IndiaDepartment of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, IndiaExtramedullary hematopoiesis (EMH) is a rare entity most often associated with primary myelofibrosis, chronic myeloproliferative neoplasms, chronic hemolytic states, such as thalassemia, sickle cell anemia and certain solid tumors. Various theories have been postulated as the mechanism for occurrence of EMH. Iron deposition and/or fatty infiltration along with increased density of liver and spleen may be observed on imaging. Also, organs may show diffuse involvement or mass like foci of hematopoiesis on imaging. Treatment includes transfusion, surgery, hydroxyurea and radiation. In this review we narrate the clinicopathological features, radiological imaging and treatment strategies of non hepatosplenic Extramedullary hematopoiesis.http://www.sciencedirect.com/science/article/pii/S2468124522005137Extramedullary hematopoiesisLiverSpleenImagingRadiation |
| spellingShingle | Sweety Gupta Ajay S. Krishnan Jyoti Singh Amit Gupta Manoj Gupta Clinicopathological characteristics and management of extramedullary hematopoiesis: A review Pediatric Hematology Oncology Journal Extramedullary hematopoiesis Liver Spleen Imaging Radiation |
| title | Clinicopathological characteristics and management of extramedullary hematopoiesis: A review |
| title_full | Clinicopathological characteristics and management of extramedullary hematopoiesis: A review |
| title_fullStr | Clinicopathological characteristics and management of extramedullary hematopoiesis: A review |
| title_full_unstemmed | Clinicopathological characteristics and management of extramedullary hematopoiesis: A review |
| title_short | Clinicopathological characteristics and management of extramedullary hematopoiesis: A review |
| title_sort | clinicopathological characteristics and management of extramedullary hematopoiesis a review |
| topic | Extramedullary hematopoiesis Liver Spleen Imaging Radiation |
| url | http://www.sciencedirect.com/science/article/pii/S2468124522005137 |
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