Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

The foremost target of the current work was to formulate and optimize a novel bergamot essential oil (BEO) loaded nano-phytosomes (NPs) and then combine it with spironolactone (SP) in order to clinically compare the efficiency of both formulations against acne vulgaris. The BEO-loaded NPs formulatio...

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Bibliographic Details
Main Authors: Rofida Albash, Noha M. Badawi, Mohammed I. A. Hamed, Maha H. Ragaie, Sahar S. Mohammed, Rovan M. Elbesh, Khaled M. Darwish, Manar O. Lashkar, Sameh S. Elhady, Shaimaa Mosallam
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
bergamot essential oil
spironolactone
nano-phytosomes
acne vulgaris
in silico study
clinical studies
Online Access:https://www.mdpi.com/1424-8247/16/1/128

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