siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect

<p>Abstract</p> <p>Background</p> <p>RNA interference (RNAi), mediated by 21-nucleotide (nt)-length small interfering RNAs (siRNAs), is a powerful tool not only for studying gene function but also for therapeutic applications. RNAi, requiring perfect complementarity bet...

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Bibliographic Details
Main Authors:	Morishita Shinichi, Yoshimura Jun, Naito Yuki, Ui-Tei Kumiko
Format:	Article
Language:	English
Published:	BMC 2009-11-01
Series:	BMC Bioinformatics
Online Access:	http://www.biomedcentral.com/1471-2105/10/392

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