Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission
Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of <i>Culicoides</i> spp., however, some BTV strains can be transmitted vertically, and this is associated with fetus malformatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/11/1528 |
| _version_ | 1797508879007875072 |
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| author | José M. Rojas Verónica Martín Noemí Sevilla |
| author_facet | José M. Rojas Verónica Martín Noemí Sevilla |
| author_sort | José M. Rojas |
| collection | DOAJ |
| description | Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of <i>Culicoides</i> spp., however, some BTV strains can be transmitted vertically, and this is associated with fetus malformations and abortions. The viral factors associated with the virus potency to cross the placental barrier are not well defined. The potency of vertical transmission is retained and sometimes even increased in live attenuated BTV vaccine strains. Because BTV possesses a segmented genome, the possibility of reassortment of vaccination strains with wild-type virus could even favor the transmission of this phenotype. In the present review, we will describe the non-vector-based BTV infection routes and discuss the experimental vaccination strategies that offer advantages over this drawback of some live attenuated BTV vaccines. |
| first_indexed | 2024-03-10T05:10:07Z |
| format | Article |
| id | doaj.art-8fd9a578af704b1bbe806bcc53ab99d1 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T05:10:07Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-8fd9a578af704b1bbe806bcc53ab99d12023-11-23T00:54:41ZengMDPI AGPathogens2076-08172021-11-011011152810.3390/pathogens10111528Vaccination as a Strategy to Prevent Bluetongue Virus Vertical TransmissionJosé M. Rojas0Verónica Martín1Noemí Sevilla2Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (CISA-INIA-CSIC), 28130 Valdeolmos, SpainCentro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (CISA-INIA-CSIC), 28130 Valdeolmos, SpainCentro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (CISA-INIA-CSIC), 28130 Valdeolmos, SpainBluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of <i>Culicoides</i> spp., however, some BTV strains can be transmitted vertically, and this is associated with fetus malformations and abortions. The viral factors associated with the virus potency to cross the placental barrier are not well defined. The potency of vertical transmission is retained and sometimes even increased in live attenuated BTV vaccine strains. Because BTV possesses a segmented genome, the possibility of reassortment of vaccination strains with wild-type virus could even favor the transmission of this phenotype. In the present review, we will describe the non-vector-based BTV infection routes and discuss the experimental vaccination strategies that offer advantages over this drawback of some live attenuated BTV vaccines.https://www.mdpi.com/2076-0817/10/11/1528orbivirusbluetonguevaccinationvertical transmissionreview |
| spellingShingle | José M. Rojas Verónica Martín Noemí Sevilla Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission Pathogens orbivirus bluetongue vaccination vertical transmission review |
| title | Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission |
| title_full | Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission |
| title_fullStr | Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission |
| title_full_unstemmed | Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission |
| title_short | Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission |
| title_sort | vaccination as a strategy to prevent bluetongue virus vertical transmission |
| topic | orbivirus bluetongue vaccination vertical transmission review |
| url | https://www.mdpi.com/2076-0817/10/11/1528 |
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