A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome Estimation
Background: Most research on children and adolescents with COVID-19, had limited sample sizes and little clinical, laboratory, and radiological findings. The purpose of this research was to examine the features of children and adolescents with COVID-19 infection.Methods: This analytical retrospectiv...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-10-01
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| Series: | International Journal of Pediatrics |
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| Online Access: | https://ijp.mums.ac.ir/article_23235_9c96f821fd57418b45867386994bbec3.pdf |
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| author | Mahsa Masjedi Esfahani Hamidreza Talari Javid Azadbakht Mohammad Mahdi Heidari Mahdi Salehi Babak Soltani Shahede Nazemi Mojtaba Ghasemi Adl Seyed Mohammad Hosein Tabatabaei |
| author_facet | Mahsa Masjedi Esfahani Hamidreza Talari Javid Azadbakht Mohammad Mahdi Heidari Mahdi Salehi Babak Soltani Shahede Nazemi Mojtaba Ghasemi Adl Seyed Mohammad Hosein Tabatabaei |
| author_sort | Mahsa Masjedi Esfahani |
| collection | DOAJ |
| description | Background: Most research on children and adolescents with COVID-19, had limited sample sizes and little clinical, laboratory, and radiological findings. The purpose of this research was to examine the features of children and adolescents with COVID-19 infection.Methods: This analytical retrospective study was conducted on children (1 to 12 years old) and adolescents (13 to 19 years old) with COVID-19 in Shahid Beheshti Hospital, Kashan, Iran. The data were then collected, entered into SPSS and analyzed.Results: In the adolescent group, the frequency of dyspnea (47.1 % vs. 11.9%), cough (67.1 % vs. 39.2%), lethargy (42.9 % vs. 25.9%), headache (35.7 % vs. 10.5%), myalgia (38.6 % vs. 14%), and chest pain (12.9 % vs. 0.7%) were significantly higher than those in children (p<0.05). Furthermore, in terms of laboratory findings, the normal range of neutrophils (13.8% vs. 1.4%), Cr (95% vs. 75.7%), and CRP (77.9% vs. 58%) were higher in children. Moreover, we found that the CT severity score among adolescent patients was significantly higher than that in children (4.84 ± 5.21 vs. 1.76 ± 3.25, p=0.006). Also, the frequency of consolidation (61.3 % vs. 19%), and ground-glass opacity (58.1 % vs. 28.6%) among adolescents were significantly higher compared to child cases (p<0.05) while only the frequency of mosaic pattern of pulmonary parenchymal attenuation was significantly higher among children (p=0.035).Conclusion: This research found milder clinical, biochemical, and radiological symptoms in children with COVID-19 than adolescents. However, radiological examinations showed greater rates of pulmonary parenchymal mosaic attenuation, which might help early diagnosis of COVID-19. |
| first_indexed | 2024-03-11T14:34:27Z |
| format | Article |
| id | doaj.art-8fdbdcb450ec4d0695f49ebc19f4b2d4 |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-03-11T14:34:27Z |
| publishDate | 2023-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-8fdbdcb450ec4d0695f49ebc19f4b2d42023-10-31T05:04:53ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552023-10-011110183271833910.22038/ijp.2023.74419.536623235A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome EstimationMahsa Masjedi Esfahani0Hamidreza Talari1Javid Azadbakht2Mohammad Mahdi Heidari3Mahdi Salehi4Babak Soltani5Shahede Nazemi6Mojtaba Ghasemi Adl7Seyed Mohammad Hosein Tabatabaei8Department of Radiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranDepartment of Radiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranDepartment of Radiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranDepartment of Pediatrics,Faculty of medicine,Kashan University of Medical Sciences, Kashan, IranStudent Research Committee, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranAssociate professor of pediatrics diseases, Department of Pediatrics, School of Medicine, Infectious Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical SciencesDepartment of Radiology, Kashan University of Medical Sciences, Kashan, IranDepartment of Radiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranDepartment of Radiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranBackground: Most research on children and adolescents with COVID-19, had limited sample sizes and little clinical, laboratory, and radiological findings. The purpose of this research was to examine the features of children and adolescents with COVID-19 infection.Methods: This analytical retrospective study was conducted on children (1 to 12 years old) and adolescents (13 to 19 years old) with COVID-19 in Shahid Beheshti Hospital, Kashan, Iran. The data were then collected, entered into SPSS and analyzed.Results: In the adolescent group, the frequency of dyspnea (47.1 % vs. 11.9%), cough (67.1 % vs. 39.2%), lethargy (42.9 % vs. 25.9%), headache (35.7 % vs. 10.5%), myalgia (38.6 % vs. 14%), and chest pain (12.9 % vs. 0.7%) were significantly higher than those in children (p<0.05). Furthermore, in terms of laboratory findings, the normal range of neutrophils (13.8% vs. 1.4%), Cr (95% vs. 75.7%), and CRP (77.9% vs. 58%) were higher in children. Moreover, we found that the CT severity score among adolescent patients was significantly higher than that in children (4.84 ± 5.21 vs. 1.76 ± 3.25, p=0.006). Also, the frequency of consolidation (61.3 % vs. 19%), and ground-glass opacity (58.1 % vs. 28.6%) among adolescents were significantly higher compared to child cases (p<0.05) while only the frequency of mosaic pattern of pulmonary parenchymal attenuation was significantly higher among children (p=0.035).Conclusion: This research found milder clinical, biochemical, and radiological symptoms in children with COVID-19 than adolescents. However, radiological examinations showed greater rates of pulmonary parenchymal mosaic attenuation, which might help early diagnosis of COVID-19.https://ijp.mums.ac.ir/article_23235_9c96f821fd57418b45867386994bbec3.pdfcoronavirus disease 2019,,,،pediatrics,,,،adolescents,,,،chest ct scan |
| spellingShingle | Mahsa Masjedi Esfahani Hamidreza Talari Javid Azadbakht Mohammad Mahdi Heidari Mahdi Salehi Babak Soltani Shahede Nazemi Mojtaba Ghasemi Adl Seyed Mohammad Hosein Tabatabaei A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome Estimation International Journal of Pediatrics coronavirus disease 2019,, ,،pediatrics,, ,،adolescents,, ,،chest ct scan |
| title | A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome Estimation |
| title_full | A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome Estimation |
| title_fullStr | A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome Estimation |
| title_full_unstemmed | A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome Estimation |
| title_short | A Comparative Evaluation of the Clinical Course, Laboratory Data and Chest CT scan Findings in Pediatric Patients with Covid-19 and Their Prognostic Value in Disease Outcome Estimation |
| title_sort | comparative evaluation of the clinical course laboratory data and chest ct scan findings in pediatric patients with covid 19 and their prognostic value in disease outcome estimation |
| topic | coronavirus disease 2019,, ,،pediatrics,, ,،adolescents,, ,،chest ct scan |
| url | https://ijp.mums.ac.ir/article_23235_9c96f821fd57418b45867386994bbec3.pdf |
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