Effective quantification of ravidasvir (an NS5A inhibitor) and sofosbuvir in rat plasma by validated LC-MS/MS method and its application to pharmacokinetic study

Effective quantification of ravidasvir (an NS5A inhibitor) and sofosbuvir in rat plasma by validated LC-MS/MS method and its application to pharmacokinetic study

HCV-genotype-4 (HCV-GT4) is the cause of approximately 20% of the 170 million cases of chronic hepatitis C virus (HCV) in the world. Around 95% of patients with chronic HCV infection can be cure by utilizing direct-acting antiviral treatment. Two anti-HCV genotype 4 co-administered ravidasvir (RAV)...

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Bibliographic Details
Main Authors: Mohamed Hefnawy, Sherif Hammad, Adnan Kadi, Nawaf Alsaif, Mostafa Mohammed, Abdullah Al-Hossaini, Yousef Bin Jardan, Mohamed Attwa, Maha Abou-El-Alamin
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Arabian Journal of Chemistry
Subjects:
LC-MS/MS
Ravidasvir
Sofosbuvir
Rat plasma
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535220303828

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