Reversal of ABCB1-related multidrug resistance by ERK5-IN-1

Reversal of ABCB1-related multidrug resistance by ERK5-IN-1

Abstract Background Inhibition of ABC transporters is considered the most effective way to circumvent multidrug resistance (MDR). In the present study, we evaluated the MDR modulatory potential of ERK5-IN-1, a potent extracelluar signal regulated kinase 5 (ERK5) inhibitor. Methods The cytotoxicity a...

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Bibliographic Details
Main Authors: Fang Wang, Delan Li, ZongHeng Zheng, Kenneth Kin Wah To, Zhen Chen, Mengjun Zhong, Xiaodong Su, Likun Chen, Liwu Fu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ERK5-IN-1
Multi-drug resistance
ATP-binding cassette transporter
ABCB1
Online Access:http://link.springer.com/article/10.1186/s13046-020-1537-9

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