Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes

Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes

Neonatal brain damage and age-related neurodegenerative disease share many common mechanisms of injury involving mitochondriopathy, oxidative stress, excitotoxicity, inflammation, and neuronal cell death. We hypothesized that genes causing adult-onset neurodegeneration can influence acute outcome af...

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Bibliographic Details
Main Authors: Lee J. Martin, Margaret Wong, Allison Hanaford
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neurology
Subjects:
neonatal brain damage
traumatic brain injury
ALS
synuclein oligomerization
Parkinson's disease
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00635/full

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