Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]

Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]

α-Conotoxin GeXIVA[1,2] is a highly potent and selective antagonist of the α9α10 nicotinic acetylcholine receptor (nAChR) subtype. It has the advantages of strong efficacy, no tolerance, and no effect on motor function, which has been expected help patients with neuropathic pain. However, drug devel...

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Bibliographic Details
Main Authors: Zhiguo Li, Xiaolu Han, Xiaoxuan Hong, Xianfu Li, Jing Gao, Hui Zhang, Aiping Zheng
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Marine Drugs
Subjects:
α-Conotoxin GeXIVA[1,2]
nicotinic acetylcholine receptors
lyophilization
molecular simulation
paclitaxel-induced neuropathic pain
analgesic effect
Online Access:https://www.mdpi.com/1660-3397/19/3/121

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