Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Administration of busulfan is extending rapidly as a part of a conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Monitoring blood plasma levels of busulfan is recommended for identifying the optimal dose in patients and for minimizing toxicity. The aim of th...

Full description

Bibliographic Details
Main Authors: Villena-Ortiz Yolanda, Castellote-Bellés Laura, Martinez-Sanchez Luisa, Benítez-Carabante María I., Miarons Marta, Vima-Bofarull Jaume, Barquin-DelPino Raquel, Paciucci Rosanna, Rodríguez-Frías Francisco, Ferrer-Costa Roser, Casis Ernesto, López-Hellín Joan
Format: Article
Language:English
Published: De Gruyter 2022-06-01
Series:Advances in Laboratory Medicine
Subjects:
hematopoietic stem cell transplantation
mass spectrometry platform
method validation
therapeutic drug monitoring
Online Access:https://doi.org/10.1515/almed-2022-0016
Description
Summary:Administration of busulfan is extending rapidly as a part of a conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Monitoring blood plasma levels of busulfan is recommended for identifying the optimal dose in patients and for minimizing toxicity. The aim of this research was to validate a simple, rapid, and cost-effective analytical tool for measuring busulfan in human plasma that would be suitable for routine clinical use. This novel tool was based on liquid chromatography coupled to mass spectrometry.
ISSN:2628-491X

Similar Items