Soluble and Cell–Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma

Soluble and Cell–Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma

It is becoming clear that myeloma cell-induced disruption of the highly organized bone marrow components (both cellular and extracellular) results in destruction of the marrow and support for multiple myeloma (MM) cell proliferation, survival, migration, and drug resistance. Since the first phase I...

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Bibliographic Details
Main Authors: Mariah L. Farrell, Michaela R. Reagan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Endocrinology
Subjects:
multiple myeloma
drug resistance
bone marrow MSCs
bortezomib
carfilzomib
ixazomib
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00218/full

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