Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation
Peripheral nerve injury can lead to chronic pain, paralysis, and loss of sensation, severely affecting quality of life. Spinal cord stimulation has been used in the clinic to provide pain relief arising from peripheral nerve injuries, however, its ability to restore function after peripheral nerve i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1210544/full |
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| author | Santosh Chandrasekaran Nikunj A. Bhagat Nikunj A. Bhagat Richard Ramdeo Sadegh Ebrahimi Pawan D. Sharma Doug G. Griffin Adam Stein Susan J. Harkema Susan J. Harkema Susan J. Harkema Susan J. Harkema Chad E. Bouton Chad E. Bouton |
| author_facet | Santosh Chandrasekaran Nikunj A. Bhagat Nikunj A. Bhagat Richard Ramdeo Sadegh Ebrahimi Pawan D. Sharma Doug G. Griffin Adam Stein Susan J. Harkema Susan J. Harkema Susan J. Harkema Susan J. Harkema Chad E. Bouton Chad E. Bouton |
| author_sort | Santosh Chandrasekaran |
| collection | DOAJ |
| description | Peripheral nerve injury can lead to chronic pain, paralysis, and loss of sensation, severely affecting quality of life. Spinal cord stimulation has been used in the clinic to provide pain relief arising from peripheral nerve injuries, however, its ability to restore function after peripheral nerve injury have not been explored. Neuromodulation of the spinal cord through transcutaneous spinal cord stimulation (tSCS), when paired with activity-based training, has shown promising results towards restoring volitional limb control in people with spinal cord injury. We show, for the first time, the effectiveness of targeted tSCS in restoring strength (407% increase from 1.79 ± 1.24 N to up to 7.3 ± 0.93 N) and significantly increasing hand dexterity in an individual with paralysis due to a peripheral nerve injury (PNI). Furthermore, this is the first study to document a persisting 3-point improvement during clinical assessment of tactile sensation in peripheral injury after receiving 6 weeks of tSCS. Lastly, the motor and sensory gains persisted for several months after stimulation was received, suggesting tSCS may lead to long-lasting benefits, even in PNI. Non-invasive spinal cord stimulation shows tremendous promise as a safe and effective therapeutic approach with broad applications in functional recovery after debilitating injuries. |
| first_indexed | 2024-03-12T23:16:33Z |
| format | Article |
| id | doaj.art-8fe697883d3f42e6bb47593682e82b2b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T23:16:33Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-8fe697883d3f42e6bb47593682e82b2b2023-07-17T06:55:04ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-07-011710.3389/fnins.2023.12105441210544Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulationSantosh Chandrasekaran0Nikunj A. Bhagat1Nikunj A. Bhagat2Richard Ramdeo3Sadegh Ebrahimi4Pawan D. Sharma5Doug G. Griffin6Adam Stein7Susan J. Harkema8Susan J. Harkema9Susan J. Harkema10Susan J. Harkema11Chad E. Bouton12Chad E. Bouton13Neural Bypass and Brain Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United StatesNeural Bypass and Brain Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United StatesDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center, Houston, TX, United StatesNeural Bypass and Brain Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United StatesNeural Bypass and Brain Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United StatesKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United StatesNorthwell Health STARS Rehabilitation, East Meadow, NY, United StatesDepartment of Physical Medicine and Rehabilitation, Donald and Barbara Zucker School of Medicine at Hofstra, Northwell Health, Manhasset, NY, United StatesKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United StatesDepartment of Bioengineering, University of Louisville, Louisville, KY, United StatesFrazier Rehabilitation Institute, University of Louisville Health, Louisville, KY, United StatesDepartment of Neurological Surgery, University of Louisville, Louisville, KY, United StatesNeural Bypass and Brain Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United StatesDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, United StatesPeripheral nerve injury can lead to chronic pain, paralysis, and loss of sensation, severely affecting quality of life. Spinal cord stimulation has been used in the clinic to provide pain relief arising from peripheral nerve injuries, however, its ability to restore function after peripheral nerve injury have not been explored. Neuromodulation of the spinal cord through transcutaneous spinal cord stimulation (tSCS), when paired with activity-based training, has shown promising results towards restoring volitional limb control in people with spinal cord injury. We show, for the first time, the effectiveness of targeted tSCS in restoring strength (407% increase from 1.79 ± 1.24 N to up to 7.3 ± 0.93 N) and significantly increasing hand dexterity in an individual with paralysis due to a peripheral nerve injury (PNI). Furthermore, this is the first study to document a persisting 3-point improvement during clinical assessment of tactile sensation in peripheral injury after receiving 6 weeks of tSCS. Lastly, the motor and sensory gains persisted for several months after stimulation was received, suggesting tSCS may lead to long-lasting benefits, even in PNI. Non-invasive spinal cord stimulation shows tremendous promise as a safe and effective therapeutic approach with broad applications in functional recovery after debilitating injuries.https://www.frontiersin.org/articles/10.3389/fnins.2023.1210544/fullperipheral nerve injury (PNI)spinal cord stimulation (SCS)neuromodulationmotor restorationtactile sensation |
| spellingShingle | Santosh Chandrasekaran Nikunj A. Bhagat Nikunj A. Bhagat Richard Ramdeo Sadegh Ebrahimi Pawan D. Sharma Doug G. Griffin Adam Stein Susan J. Harkema Susan J. Harkema Susan J. Harkema Susan J. Harkema Chad E. Bouton Chad E. Bouton Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation Frontiers in Neuroscience peripheral nerve injury (PNI) spinal cord stimulation (SCS) neuromodulation motor restoration tactile sensation |
| title | Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation |
| title_full | Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation |
| title_fullStr | Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation |
| title_full_unstemmed | Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation |
| title_short | Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation |
| title_sort | case study persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation |
| topic | peripheral nerve injury (PNI) spinal cord stimulation (SCS) neuromodulation motor restoration tactile sensation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1210544/full |
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