Platelet indices significantly correlate with liver fibrosis in HCV-infected patients.
AIM:A total of 241 patients with chronic HCV infection were recruited to investigate the association between liver fibrosis and PLT counts, as well as with MPV, PDW and P-LCR indices. METHODS:The determination of PLT indices was carried out using a Sysmex XT-1800i automated hematology analyzer. Sero...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0227544 |
| _version_ | 1818678165725249536 |
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| author | Lin-Nan Shao Shu-Ting Zhang Ni Wang Wei-Jian Yu Mei Chen Nan Xiao Ying Duan Ling-Zi Pan Wen-Qian Song Yue-Xin Xia Li Zhang Ning Qi Ming Liu Shi-Hang Zhou |
| author_facet | Lin-Nan Shao Shu-Ting Zhang Ni Wang Wei-Jian Yu Mei Chen Nan Xiao Ying Duan Ling-Zi Pan Wen-Qian Song Yue-Xin Xia Li Zhang Ning Qi Ming Liu Shi-Hang Zhou |
| author_sort | Lin-Nan Shao |
| collection | DOAJ |
| description | AIM:A total of 241 patients with chronic HCV infection were recruited to investigate the association between liver fibrosis and PLT counts, as well as with MPV, PDW and P-LCR indices. METHODS:The determination of PLT indices was carried out using a Sysmex XT-1800i automated hematology analyzer. Serological tests for HA, LN, C-IV and PIIINP were performed in 210 patients. The liver stiffness was measured in 69 patients by transient elastography (FibroScan). RESULTS:The analysis showed that the four serum fibrosis markers were negatively correlated with PLT counts, but positively correlated with the MPV, PDW and P-LCR values. Moreover, a similar pattern was found after analyzing the FibroScan measurements, which were negatively correlated with PLT counts, but positively correlated with MPV, PDW and P-LCR values. We subdivided the HCV-infected patients into mild and advanced fibrosis groups. The PLT counts were significantly decreased and the MPV, PDW and P-LCR values were significantly increased in the advanced fibrosis group when compared with the mild fibrosis group. CONCLUSIONS:Our results demonstrate that not only the PLT counts but also the MPV, PDW and P-LCR indices significantly correlate with liver fibrosis in HCV-infected patients. Therefore, these indices may be useful laboratory measures for evaluating liver fibrosis progression. |
| first_indexed | 2024-12-17T09:10:56Z |
| format | Article |
| id | doaj.art-8fe7be60feac4ca7b89e082ffc6bf715 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:10:56Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8fe7be60feac4ca7b89e082ffc6bf7152022-12-21T21:55:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01151e022754410.1371/journal.pone.0227544Platelet indices significantly correlate with liver fibrosis in HCV-infected patients.Lin-Nan ShaoShu-Ting ZhangNi WangWei-Jian YuMei ChenNan XiaoYing DuanLing-Zi PanWen-Qian SongYue-Xin XiaLi ZhangNing QiMing LiuShi-Hang ZhouAIM:A total of 241 patients with chronic HCV infection were recruited to investigate the association between liver fibrosis and PLT counts, as well as with MPV, PDW and P-LCR indices. METHODS:The determination of PLT indices was carried out using a Sysmex XT-1800i automated hematology analyzer. Serological tests for HA, LN, C-IV and PIIINP were performed in 210 patients. The liver stiffness was measured in 69 patients by transient elastography (FibroScan). RESULTS:The analysis showed that the four serum fibrosis markers were negatively correlated with PLT counts, but positively correlated with the MPV, PDW and P-LCR values. Moreover, a similar pattern was found after analyzing the FibroScan measurements, which were negatively correlated with PLT counts, but positively correlated with MPV, PDW and P-LCR values. We subdivided the HCV-infected patients into mild and advanced fibrosis groups. The PLT counts were significantly decreased and the MPV, PDW and P-LCR values were significantly increased in the advanced fibrosis group when compared with the mild fibrosis group. CONCLUSIONS:Our results demonstrate that not only the PLT counts but also the MPV, PDW and P-LCR indices significantly correlate with liver fibrosis in HCV-infected patients. Therefore, these indices may be useful laboratory measures for evaluating liver fibrosis progression.https://doi.org/10.1371/journal.pone.0227544 |
| spellingShingle | Lin-Nan Shao Shu-Ting Zhang Ni Wang Wei-Jian Yu Mei Chen Nan Xiao Ying Duan Ling-Zi Pan Wen-Qian Song Yue-Xin Xia Li Zhang Ning Qi Ming Liu Shi-Hang Zhou Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. PLoS ONE |
| title | Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. |
| title_full | Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. |
| title_fullStr | Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. |
| title_full_unstemmed | Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. |
| title_short | Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. |
| title_sort | platelet indices significantly correlate with liver fibrosis in hcv infected patients |
| url | https://doi.org/10.1371/journal.pone.0227544 |
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