Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study
<i>Background and Objectives</i>: In October 2018, the International Federation of Gynecology and Obstetrics (FIGO) revised its classification of advanced stages of cervical cancer. The main points of the classification are as follows: stage IIIC is newly established; pelvic lymph node m...
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MDPI AG
2021-05-01
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| author | Masahiro Kagabu Takayuki Nagasawa Shunsuke Tatsuki Yasuko Fukagawa Hidetoshi Tomabechi Eriko Takatori Yoshitaka Kaido Tadahiro Shoji Tsukasa Baba |
| author_facet | Masahiro Kagabu Takayuki Nagasawa Shunsuke Tatsuki Yasuko Fukagawa Hidetoshi Tomabechi Eriko Takatori Yoshitaka Kaido Tadahiro Shoji Tsukasa Baba |
| author_sort | Masahiro Kagabu |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: In October 2018, the International Federation of Gynecology and Obstetrics (FIGO) revised its classification of advanced stages of cervical cancer. The main points of the classification are as follows: stage IIIC is newly established; pelvic lymph node metastasis is stage IIIC1; and para-aortic lymph node metastasis is stage IIIC2. Currently, in Japan, radical hysterectomy is performed in advanced stages IA2 to IIB of FIGO2014, and concurrent chemoradiotherapy (CCRT) is recommended for patients with positive lymph nodes. However, the efficacy of CCRT is not always satisfactory. The aim of this study was to compare postoperative adjuvant chemotherapy (CT) and postoperative CCRT in stage IIIC1 patients. <i>Materials and Methods</i>: Of the 40 patients who had undergone a radical hysterectomy at Iwate Medical University between January 2011 and December 2016 and were pathologically diagnosed as having positive pelvic lymph nodes, 21 patients in the adjuvant CT group and 19 patients in the postoperative CCRT group were compared. <i>Results</i>: The 5 year survival rates were 77.9% in the CT group and 74.7% in the CCRT group, with no significant difference. There was no significant difference in overall survival or progression-free survival between the two groups. There was no significant difference between CT and CCRT in postoperative adjuvant therapy in the new classification IIIC1 stage. <i>Conclusions</i>: The results of the prospective Japanese Gynecologic Oncology Group (JGOG) 1082 study are pending, but the present results suggest that CT may be a treatment option in rural areas where radiotherapy facilities are limited. |
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| language | English |
| last_indexed | 2024-03-10T10:53:48Z |
| publishDate | 2021-05-01 |
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| series | Medicina |
| spelling | doaj.art-8fe8762e895a48c08de988beef505bc12023-11-21T22:00:51ZengMDPI AGMedicina1010-660X1648-91442021-05-0157654810.3390/medicina57060548Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective StudyMasahiro Kagabu0Takayuki Nagasawa1Shunsuke Tatsuki2Yasuko Fukagawa3Hidetoshi Tomabechi4Eriko Takatori5Yoshitaka Kaido6Tadahiro Shoji7Tsukasa Baba8Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, JapanDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Shiwa, Iwate 028-3695, Japan<i>Background and Objectives</i>: In October 2018, the International Federation of Gynecology and Obstetrics (FIGO) revised its classification of advanced stages of cervical cancer. The main points of the classification are as follows: stage IIIC is newly established; pelvic lymph node metastasis is stage IIIC1; and para-aortic lymph node metastasis is stage IIIC2. Currently, in Japan, radical hysterectomy is performed in advanced stages IA2 to IIB of FIGO2014, and concurrent chemoradiotherapy (CCRT) is recommended for patients with positive lymph nodes. However, the efficacy of CCRT is not always satisfactory. The aim of this study was to compare postoperative adjuvant chemotherapy (CT) and postoperative CCRT in stage IIIC1 patients. <i>Materials and Methods</i>: Of the 40 patients who had undergone a radical hysterectomy at Iwate Medical University between January 2011 and December 2016 and were pathologically diagnosed as having positive pelvic lymph nodes, 21 patients in the adjuvant CT group and 19 patients in the postoperative CCRT group were compared. <i>Results</i>: The 5 year survival rates were 77.9% in the CT group and 74.7% in the CCRT group, with no significant difference. There was no significant difference in overall survival or progression-free survival between the two groups. There was no significant difference between CT and CCRT in postoperative adjuvant therapy in the new classification IIIC1 stage. <i>Conclusions</i>: The results of the prospective Japanese Gynecologic Oncology Group (JGOG) 1082 study are pending, but the present results suggest that CT may be a treatment option in rural areas where radiotherapy facilities are limited.https://www.mdpi.com/1648-9144/57/6/548cervical cancerInternational Federation of Gynecology and Obstetricspostoperative adjuvant therapysystemic chemotherapyconcurrent chemoradiotherapy |
| spellingShingle | Masahiro Kagabu Takayuki Nagasawa Shunsuke Tatsuki Yasuko Fukagawa Hidetoshi Tomabechi Eriko Takatori Yoshitaka Kaido Tadahiro Shoji Tsukasa Baba Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study Medicina cervical cancer International Federation of Gynecology and Obstetrics postoperative adjuvant therapy systemic chemotherapy concurrent chemoradiotherapy |
| title | Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study |
| title_full | Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study |
| title_fullStr | Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study |
| title_full_unstemmed | Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study |
| title_short | Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study |
| title_sort | comparison of postoperative adjuvant chemotherapy and concurrent chemoradiotherapy for figo2018 stage iiic1 cervical cancer a retrospective study |
| topic | cervical cancer International Federation of Gynecology and Obstetrics postoperative adjuvant therapy systemic chemotherapy concurrent chemoradiotherapy |
| url | https://www.mdpi.com/1648-9144/57/6/548 |
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