Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Upon infection, Mycobacterium leprae, an obligate intracellular bacillus, induces accumulation of cholesterol-enriched lipid droplets (LDs) in Schwann cells (SCs). LDs are promptly recruited to M. leprae-containing phagosomes, and inhibition of this process decreases bacterial survival, suggesting t...

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Bibliographic Details
Main Authors: Thabatta L. S. A. Rosa, Maria Angela M. Marques, Zachary DeBoard, Kelly Hutchins, Carlos Adriano A. Silva, Christine R. Montague, Tianao Yuan, Julio J. Amaral, Georgia C. Atella, Patrícia S. Rosa, Katherine A. Mattos, Brian C. VanderVen, Ramanuj Lahiri, Nicole S. Sampson, Patrick J. Brennan, John T. Belisle, Maria Cristina V. Pessolani, Marcia Berrêdo-Pinho
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium leprae
cholesterol
cholestenone
PGL-I
PDIM
3β-HSD
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.709972/full

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