Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14756366.2017.1381090 |
| _version_ | 1818973094946013184 |
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| author | Ban-Feng Ruan Wei-Wei Ge Hui-Jie Cheng Hua-Jian Xu Qing-Shan Li Xin-Hua Liu |
| author_facet | Ban-Feng Ruan Wei-Wei Ge Hui-Jie Cheng Hua-Jian Xu Qing-Shan Li Xin-Hua Liu |
| author_sort | Ban-Feng Ruan |
| collection | DOAJ |
| description | Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway. |
| first_indexed | 2024-12-20T15:18:42Z |
| format | Article |
| id | doaj.art-8fed6a55a59340a6914ab3c4484c419a |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-12-20T15:18:42Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-8fed6a55a59340a6914ab3c4484c419a2022-12-21T19:36:08ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742017-01-013211282129010.1080/14756366.2017.13810901381090Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activityBan-Feng Ruan0Wei-Wei Ge1Hui-Jie Cheng2Hua-Jian Xu3Qing-Shan Li4Xin-Hua Liu5Hefei University of TechnologyHefei University of TechnologyHefei University of TechnologyHefei University of TechnologyHefei University of TechnologySchool of Pharmacy, Anhui Medical UniversityTwenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.http://dx.doi.org/10.1080/14756366.2017.1381090Resveratrol derivativescinnamic esteranti-inflammatoryNF-κB signaling pathwaymolecular docking |
| spellingShingle | Ban-Feng Ruan Wei-Wei Ge Hui-Jie Cheng Hua-Jian Xu Qing-Shan Li Xin-Hua Liu Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity Journal of Enzyme Inhibition and Medicinal Chemistry Resveratrol derivatives cinnamic ester anti-inflammatory NF-κB signaling pathway molecular docking |
| title | Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity |
| title_full | Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity |
| title_fullStr | Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity |
| title_full_unstemmed | Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity |
| title_short | Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity |
| title_sort | resveratrol based cinnamic ester hybrids synthesis characterization and anti inflammatory activity |
| topic | Resveratrol derivatives cinnamic ester anti-inflammatory NF-κB signaling pathway molecular docking |
| url | http://dx.doi.org/10.1080/14756366.2017.1381090 |
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