Clinical and Experimental Advances in Regeneration of Spinal Cord Injury
Spinal cord injury (SCI) is one of the major disabilities dealt with in clinical rehabilitation settings and is multifactorial in that the patients suffer from motor and sensory impairments as well as many other complications throughout their lifetimes. Many clini...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2010-01-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | http://tej.sagepub.com/content/1/1/10.4061_2010/650857.full.pdf |
| _version_ | 1819205191560331264 |
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| author | Jung Keun Hyun Hae-Won Kim |
| author_facet | Jung Keun Hyun Hae-Won Kim |
| author_sort | Jung Keun Hyun |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is one of the major disabilities dealt
with in clinical rehabilitation settings and is multifactorial in that the patients
suffer from motor and sensory impairments as well as many other complications throughout
their lifetimes. Many clinical trials have been documented during the last two decades
to restore damaged spinal cords. However, only a few pharmacological therapies used in
clinical settings which still have only limited effects on the regeneration, recovery
speed, or retraining of the spinal cord. In this paper, we will introduce recent
clinical trials, which performed pharmacological treatments and cell transplantations
for patients with SCI, and evaluate recent in vivo studies for the regeneration of
injured spinal cord, including stem-cell transplantation, application of neurotrophic
factors and suppressor of inhibiting factors, development of biomaterial scaffolds and
delivery systems, rehabilitation, and the combinations of these therapies to evaluate
what can be appropriately applied in the future to the patients with SCI. |
| first_indexed | 2024-12-23T04:47:47Z |
| format | Article |
| id | doaj.art-8fefb9f92fe84c469a09e083e721a5aa |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-23T04:47:47Z |
| publishDate | 2010-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-8fefb9f92fe84c469a09e083e721a5aa2022-12-21T17:59:34ZengSAGE PublishingJournal of Tissue Engineering2041-73142010-01-011110.4061/2010/65085710.4061_2010/650857Clinical and Experimental Advances in Regeneration of Spinal Cord InjuryJung Keun HyunHae-Won KimSpinal cord injury (SCI) is one of the major disabilities dealt with in clinical rehabilitation settings and is multifactorial in that the patients suffer from motor and sensory impairments as well as many other complications throughout their lifetimes. Many clinical trials have been documented during the last two decades to restore damaged spinal cords. However, only a few pharmacological therapies used in clinical settings which still have only limited effects on the regeneration, recovery speed, or retraining of the spinal cord. In this paper, we will introduce recent clinical trials, which performed pharmacological treatments and cell transplantations for patients with SCI, and evaluate recent in vivo studies for the regeneration of injured spinal cord, including stem-cell transplantation, application of neurotrophic factors and suppressor of inhibiting factors, development of biomaterial scaffolds and delivery systems, rehabilitation, and the combinations of these therapies to evaluate what can be appropriately applied in the future to the patients with SCI.http://tej.sagepub.com/content/1/1/10.4061_2010/650857.full.pdf |
| spellingShingle | Jung Keun Hyun Hae-Won Kim Clinical and Experimental Advances in Regeneration of Spinal Cord Injury Journal of Tissue Engineering |
| title | Clinical and Experimental Advances in Regeneration of Spinal Cord
Injury |
| title_full | Clinical and Experimental Advances in Regeneration of Spinal Cord
Injury |
| title_fullStr | Clinical and Experimental Advances in Regeneration of Spinal Cord
Injury |
| title_full_unstemmed | Clinical and Experimental Advances in Regeneration of Spinal Cord
Injury |
| title_short | Clinical and Experimental Advances in Regeneration of Spinal Cord
Injury |
| title_sort | clinical and experimental advances in regeneration of spinal cord injury |
| url | http://tej.sagepub.com/content/1/1/10.4061_2010/650857.full.pdf |
| work_keys_str_mv | AT jungkeunhyun clinicalandexperimentaladvancesinregenerationofspinalcordinjury AT haewonkim clinicalandexperimentaladvancesinregenerationofspinalcordinjury |