Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries
Traumatic central nervous system (CNS) injury often causes irreversible impairment, and new alternative therapies for the treatment of CNS injury and sequelae are expected to be developed. Recently, mesenchymal stromal cells (MSCs) have started being used as cell therapy for neurological disorders s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-03-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102044 |
| _version_ | 1818041241091178496 |
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| author | Takeo Mukai Kenshi Sei Tokiko Nagamura-Inoue |
| author_facet | Takeo Mukai Kenshi Sei Tokiko Nagamura-Inoue |
| author_sort | Takeo Mukai |
| collection | DOAJ |
| description | Traumatic central nervous system (CNS) injury often causes irreversible impairment, and new alternative therapies for the treatment of CNS injury and sequelae are expected to be developed. Recently, mesenchymal stromal cells (MSCs) have started being used as cell therapy for neurological disorders such as traumatic CNS injury based on their immunomodulatory, neuroprotective, and neurorestorative abilities. Based on the premise of basic research, numerous clinical trials using MSCs for the treatment of traumatic CNS injury have been performed, and the feasibility and efficacy of this therapy have been reported. In this review we aimed to shed light on the characteristics of MSCs and to discuss the basic and clinical research and recent progress in clinical studies using MSCs to treat various traumatic neurological injuries. |
| first_indexed | 2024-12-10T08:27:17Z |
| format | Article |
| id | doaj.art-8fefce6a79bd424489a4055f89562475 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-12-10T08:27:17Z |
| publishDate | 2022-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-8fefce6a79bd424489a4055f895624752022-12-22T01:56:12ZengIMR PressJournal of Integrative Neuroscience0219-63522022-03-0121204410.31083/j.jin2102044S0219-6352(22)00304-7Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuriesTakeo Mukai0Kenshi Sei1Tokiko Nagamura-Inoue2Department of Pediatrics, The University of Tokyo Hospital, 113-8655 Hongo, Bunkyo-Ku, Tokyo, JapanDepartment of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo,108-8639 Shirokanedai, Minato-Ku, Tokyo, JapanDepartment of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo,108-8639 Shirokanedai, Minato-Ku, Tokyo, JapanTraumatic central nervous system (CNS) injury often causes irreversible impairment, and new alternative therapies for the treatment of CNS injury and sequelae are expected to be developed. Recently, mesenchymal stromal cells (MSCs) have started being used as cell therapy for neurological disorders such as traumatic CNS injury based on their immunomodulatory, neuroprotective, and neurorestorative abilities. Based on the premise of basic research, numerous clinical trials using MSCs for the treatment of traumatic CNS injury have been performed, and the feasibility and efficacy of this therapy have been reported. In this review we aimed to shed light on the characteristics of MSCs and to discuss the basic and clinical research and recent progress in clinical studies using MSCs to treat various traumatic neurological injuries.https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102044mesenchymal stromal celltraumatic central nervous system injuryneurological disordersumbilical cordneurotrophic factors |
| spellingShingle | Takeo Mukai Kenshi Sei Tokiko Nagamura-Inoue Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries Journal of Integrative Neuroscience mesenchymal stromal cell traumatic central nervous system injury neurological disorders umbilical cord neurotrophic factors |
| title | Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries |
| title_full | Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries |
| title_fullStr | Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries |
| title_full_unstemmed | Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries |
| title_short | Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries |
| title_sort | mesenchymal stromal cells cell based therapies for traumatic central nervous system injuries |
| topic | mesenchymal stromal cell traumatic central nervous system injury neurological disorders umbilical cord neurotrophic factors |
| url | https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102044 |
| work_keys_str_mv | AT takeomukai mesenchymalstromalcellscellbasedtherapiesfortraumaticcentralnervoussysteminjuries AT kenshisei mesenchymalstromalcellscellbasedtherapiesfortraumaticcentralnervoussysteminjuries AT tokikonagamurainoue mesenchymalstromalcellscellbasedtherapiesfortraumaticcentralnervoussysteminjuries |