Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications
Nanoparticles (NPs) have gained great attention in recent years due to their extensive and innovative applications in the field of medicine. However, conventional physicochemical approaches for the synthesis of NPs may be limited and costly, and the reaction by-products are potentially toxic for hum...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Nanotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2022.823236/full |
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| author | Andréa Cristina Bogas Saulo Henrique Rodrigues Mariana Ottaiano Gonçalves Marcelo De Assis Elson Longo Cristina Paiva De Sousa |
| author_facet | Andréa Cristina Bogas Saulo Henrique Rodrigues Mariana Ottaiano Gonçalves Marcelo De Assis Elson Longo Cristina Paiva De Sousa |
| author_sort | Andréa Cristina Bogas |
| collection | DOAJ |
| description | Nanoparticles (NPs) have gained great attention in recent years due to their extensive and innovative applications in the field of medicine. However, conventional physicochemical approaches for the synthesis of NPs may be limited and costly, and the reaction by-products are potentially toxic for human health and the environment. Bio-mediated synthesis of NPs exploiting microorganisms as nanofactories has emerged as an alternative to traditional methods, as it provides economic and environmental benefits. Tropical ecosystems harbor a high diversity of endophytes, which have a diverse array of metabolic pathways that confer habitat adaptation and survival and that can be used to produce novel bioactive compounds with a variety of biological properties. Endophytic bacteria and fungi cultivated under optimum conditions have potential for use in biogenic synthesis of NPs with different characteristics and desired activities for medical applications, such as antimicrobial, antitumoral, antioxidant and anti-inflammatory properties. The bio-mediated synthesis of metal-based NPs can be favored because endophytic microorganisms may tolerate and/or adsorb metals and produce enzymes used as reducing agents. To our knowledge, this is the first review that brings together exclusively current research highlighting on the potential of endophytic bacteria and fungi isolated from native plants or adapted to tropical ecosystems and tropical macroalgae as nanofactories for the synthesis of NPs of silver, gold, copper, iron, zinc and other most studied metals, in addition to showing their potential use in human health. |
| first_indexed | 2024-12-20T17:43:13Z |
| format | Article |
| id | doaj.art-8fefcfae2b3743f2a6187e3af5a5aee1 |
| institution | Directory Open Access Journal |
| issn | 2673-3013 |
| language | English |
| last_indexed | 2024-12-20T17:43:13Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj.art-8fefcfae2b3743f2a6187e3af5a5aee12022-12-21T19:31:02ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132022-02-01410.3389/fnano.2022.823236823236Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare ApplicationsAndréa Cristina Bogas0Saulo Henrique Rodrigues1Mariana Ottaiano Gonçalves2Marcelo De Assis3Elson Longo4Cristina Paiva De Sousa5Department of Morphology and Pathology (DMP), Federal University of São Carlos, São Carlos, BrazilDepartment of Morphology and Pathology (DMP), Federal University of São Carlos, São Carlos, BrazilDepartment of Morphology and Pathology (DMP), Federal University of São Carlos, São Carlos, BrazilDepartment of Chemistry, Federal University of São Carlos, São Carlos, BrazilDepartment of Chemistry, Federal University of São Carlos, São Carlos, BrazilDepartment of Morphology and Pathology (DMP), Federal University of São Carlos, São Carlos, BrazilNanoparticles (NPs) have gained great attention in recent years due to their extensive and innovative applications in the field of medicine. However, conventional physicochemical approaches for the synthesis of NPs may be limited and costly, and the reaction by-products are potentially toxic for human health and the environment. Bio-mediated synthesis of NPs exploiting microorganisms as nanofactories has emerged as an alternative to traditional methods, as it provides economic and environmental benefits. Tropical ecosystems harbor a high diversity of endophytes, which have a diverse array of metabolic pathways that confer habitat adaptation and survival and that can be used to produce novel bioactive compounds with a variety of biological properties. Endophytic bacteria and fungi cultivated under optimum conditions have potential for use in biogenic synthesis of NPs with different characteristics and desired activities for medical applications, such as antimicrobial, antitumoral, antioxidant and anti-inflammatory properties. The bio-mediated synthesis of metal-based NPs can be favored because endophytic microorganisms may tolerate and/or adsorb metals and produce enzymes used as reducing agents. To our knowledge, this is the first review that brings together exclusively current research highlighting on the potential of endophytic bacteria and fungi isolated from native plants or adapted to tropical ecosystems and tropical macroalgae as nanofactories for the synthesis of NPs of silver, gold, copper, iron, zinc and other most studied metals, in addition to showing their potential use in human health.https://www.frontiersin.org/articles/10.3389/fnano.2022.823236/fullendophytetropicsbioactive compoundsgreen synthesisnanoparticlesmedicine |
| spellingShingle | Andréa Cristina Bogas Saulo Henrique Rodrigues Mariana Ottaiano Gonçalves Marcelo De Assis Elson Longo Cristina Paiva De Sousa Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications Frontiers in Nanotechnology endophyte tropics bioactive compounds green synthesis nanoparticles medicine |
| title | Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications |
| title_full | Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications |
| title_fullStr | Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications |
| title_full_unstemmed | Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications |
| title_short | Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications |
| title_sort | endophytic microorganisms from the tropics as biofactories for the synthesis of metal based nanoparticles healthcare applications |
| topic | endophyte tropics bioactive compounds green synthesis nanoparticles medicine |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2022.823236/full |
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