Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma
Key message Hemophagocytic lymphohistiocytosis (HLH) has been reported as a rare complication of immune checkpoint inhibitors (ICI); however, ICI‐related HLH is a life‐threatening and comparatively late adverse event. Early diagnosis is critical, and it should be included in the differential diagnos...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.1117 |
| _version_ | 1797857759997198336 |
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| author | Setsuko Oyama Tatsuya Shirai Yukiko Abe Maya Tsuchiya Toshiya Inui Kozo Suhara Satoshi Noto Mitsuhiro Kamimura |
| author_facet | Setsuko Oyama Tatsuya Shirai Yukiko Abe Maya Tsuchiya Toshiya Inui Kozo Suhara Satoshi Noto Mitsuhiro Kamimura |
| author_sort | Setsuko Oyama |
| collection | DOAJ |
| description | Key message Hemophagocytic lymphohistiocytosis (HLH) has been reported as a rare complication of immune checkpoint inhibitors (ICI); however, ICI‐related HLH is a life‐threatening and comparatively late adverse event. Early diagnosis is critical, and it should be included in the differential diagnosis especially in patients with cytopenia with fever and hyperferritinaemia. |
| first_indexed | 2024-04-09T21:01:59Z |
| format | Article |
| id | doaj.art-8ff09e62b1694333832c197f3eaf80af |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-04-09T21:01:59Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-8ff09e62b1694333832c197f3eaf80af2023-03-29T08:50:30ZengWileyRespirology Case Reports2051-33802023-04-01114n/an/a10.1002/rcr2.1117Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinomaSetsuko Oyama0Tatsuya Shirai1Yukiko Abe2Maya Tsuchiya3Toshiya Inui4Kozo Suhara5Satoshi Noto6Mitsuhiro Kamimura7Department of Respiratory Medicine National Hospital Organization Disaster Medical Center Tokyo JapanDepartment of Respiratory Medicine National Hospital Organization Disaster Medical Center Tokyo JapanDepartment of Respiratory Medicine National Hospital Organization Disaster Medical Center Tokyo JapanDepartment of Respiratory Medicine National Hospital Organization Disaster Medical Center Tokyo JapanDepartment of Respiratory Medicine National Hospital Organization Disaster Medical Center Tokyo JapanDepartment of Respiratory Medicine National Hospital Organization Disaster Medical Center Tokyo JapanHematology Division National Hospital Organization Disaster Medical Center Tokyo JapanDepartment of Respiratory Medicine National Hospital Organization Disaster Medical Center Tokyo JapanKey message Hemophagocytic lymphohistiocytosis (HLH) has been reported as a rare complication of immune checkpoint inhibitors (ICI); however, ICI‐related HLH is a life‐threatening and comparatively late adverse event. Early diagnosis is critical, and it should be included in the differential diagnosis especially in patients with cytopenia with fever and hyperferritinaemia.https://doi.org/10.1002/rcr2.1117haemophagocytic lymphohistiocytosisimmune checkpoint inhibitorslung cancer |
| spellingShingle | Setsuko Oyama Tatsuya Shirai Yukiko Abe Maya Tsuchiya Toshiya Inui Kozo Suhara Satoshi Noto Mitsuhiro Kamimura Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma Respirology Case Reports haemophagocytic lymphohistiocytosis immune checkpoint inhibitors lung cancer |
| title | Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma |
| title_full | Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma |
| title_fullStr | Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma |
| title_full_unstemmed | Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma |
| title_short | Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma |
| title_sort | immune checkpoint inhibitor related haemophagocytic lymphohistiocytosis in a patient with non small cell lung carcinoma |
| topic | haemophagocytic lymphohistiocytosis immune checkpoint inhibitors lung cancer |
| url | https://doi.org/10.1002/rcr2.1117 |
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