Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae)
Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. <i>Melicope lunu-ankenda</i> is one <i>Melicope</i> species (family <i>Rutaceae</i>), which is widely used in traditional medicine, consumed as a salad and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-08-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/17/3109 |
| _version_ | 1818657695486443520 |
|---|---|
| author | Zeinab Abdulwanis Mohamed Enas Mohamed Eliaser Emanuela Mazzon Patrick Rollin Gwendoline Cheng Lian Ee Ahmad Faizal Abdull Razis |
| author_facet | Zeinab Abdulwanis Mohamed Enas Mohamed Eliaser Emanuela Mazzon Patrick Rollin Gwendoline Cheng Lian Ee Ahmad Faizal Abdull Razis |
| author_sort | Zeinab Abdulwanis Mohamed |
| collection | DOAJ |
| description | Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. <i>Melicope lunu-ankenda</i> is one <i>Melicope</i> species (family <i>Rutaceae</i>), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the <i>M. lunu-ankenda</i> plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of <i>M. lunu-ankenda</i> major secondary metabolites in neurodegenerative diseases. |
| first_indexed | 2024-12-17T03:45:34Z |
| format | Article |
| id | doaj.art-8ff15f4e394644c89889e2c9fa8bbaf9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-17T03:45:34Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8ff15f4e394644c89889e2c9fa8bbaf92022-12-21T22:04:53ZengMDPI AGMolecules1420-30492019-08-012417310910.3390/molecules24173109molecules24173109Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae)Zeinab Abdulwanis Mohamed0Enas Mohamed Eliaser1Emanuela Mazzon2Patrick Rollin3Gwendoline Cheng Lian Ee4Ahmad Faizal Abdull Razis5Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyUniversité d’Orléans et CNRS, ICOA, UMR 7311, BP 6759, F-45067 Orléans, FranceChemistry Department, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaPlant natural compounds have great potential as alternative medicines for preventing and treating diseases. <i>Melicope lunu-ankenda</i> is one <i>Melicope</i> species (family <i>Rutaceae</i>), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the <i>M. lunu-ankenda</i> plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of <i>M. lunu-ankenda</i> major secondary metabolites in neurodegenerative diseases.https://www.mdpi.com/1420-3049/24/17/3109polyphenolscoumarinsalkaloids<i>Melicope lunu-ankenda</i>neuroprotectionneurodegenerative diseases |
| spellingShingle | Zeinab Abdulwanis Mohamed Enas Mohamed Eliaser Emanuela Mazzon Patrick Rollin Gwendoline Cheng Lian Ee Ahmad Faizal Abdull Razis Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae) Molecules polyphenols coumarins alkaloids <i>Melicope lunu-ankenda</i> neuroprotection neurodegenerative diseases |
| title | Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae) |
| title_full | Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae) |
| title_fullStr | Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae) |
| title_full_unstemmed | Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae) |
| title_short | Neuroprotective Potential of Secondary Metabolites from <i>Melicope lunu-ankenda</i> (Rutaceae) |
| title_sort | neuroprotective potential of secondary metabolites from i melicope lunu ankenda i rutaceae |
| topic | polyphenols coumarins alkaloids <i>Melicope lunu-ankenda</i> neuroprotection neurodegenerative diseases |
| url | https://www.mdpi.com/1420-3049/24/17/3109 |
| work_keys_str_mv | AT zeinababdulwanismohamed neuroprotectivepotentialofsecondarymetabolitesfromimelicopelunuankendairutaceae AT enasmohamedeliaser neuroprotectivepotentialofsecondarymetabolitesfromimelicopelunuankendairutaceae AT emanuelamazzon neuroprotectivepotentialofsecondarymetabolitesfromimelicopelunuankendairutaceae AT patrickrollin neuroprotectivepotentialofsecondarymetabolitesfromimelicopelunuankendairutaceae AT gwendolinechenglianee neuroprotectivepotentialofsecondarymetabolitesfromimelicopelunuankendairutaceae AT ahmadfaizalabdullrazis neuroprotectivepotentialofsecondarymetabolitesfromimelicopelunuankendairutaceae |