Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering
Cartilage dysfunctions caused by congenital disease, trauma and osteoarthritis are still a serious threat to joint activity and quality of life, potentially leading to disability. The relatively well-established tissue engineering technology based on hydrogel is a promising strategy for cartilage de...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.951513/full |
| _version_ | 1818546650171310080 |
|---|---|
| author | Yunong Ao En Zhang Yangxi Liu Liu Yang Jun Li Jun Li Fuyou Wang |
| author_facet | Yunong Ao En Zhang Yangxi Liu Liu Yang Jun Li Jun Li Fuyou Wang |
| author_sort | Yunong Ao |
| collection | DOAJ |
| description | Cartilage dysfunctions caused by congenital disease, trauma and osteoarthritis are still a serious threat to joint activity and quality of life, potentially leading to disability. The relatively well-established tissue engineering technology based on hydrogel is a promising strategy for cartilage defect repairing. However, several unmet challenges remain to be resolved before its wide application and clinical translation, such as weak mechanical property and compromised bioactivity. The development of nanomedicine has brought a new dawn to cartilage tissue engineering, and composite hydrogel containing nanoparticles can substantially mimic natural cartilage components with good histocompatibility, demonstrating unique biological effects. In this review, we summarize the different advanced nanoparticle hydrogels currently adopted in cartilage tissue engineering. In addition, we also discuss the various application scenarios including injection and fabrication strategies of nanocomposite hydrogel in the field of cartilage repair. Finally, the future application prospects and challenges of nanocomposite hydrogel are also highlighted. |
| first_indexed | 2024-12-12T07:56:04Z |
| format | Article |
| id | doaj.art-8ff18db7878b44a4b9a70e4314d75d3e |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T07:56:04Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-8ff18db7878b44a4b9a70e4314d75d3e2022-12-22T00:32:18ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.951513951513Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue EngineeringYunong Ao0En Zhang1Yangxi Liu2Liu Yang3Jun Li4Jun Li5Fuyou Wang6Center for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaChongqing Institute for Food and Drug Control, Chongqing, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing, ChinaCenter for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaCenter for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaChongqing Institute for Food and Drug Control, Chongqing, ChinaCenter for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaCartilage dysfunctions caused by congenital disease, trauma and osteoarthritis are still a serious threat to joint activity and quality of life, potentially leading to disability. The relatively well-established tissue engineering technology based on hydrogel is a promising strategy for cartilage defect repairing. However, several unmet challenges remain to be resolved before its wide application and clinical translation, such as weak mechanical property and compromised bioactivity. The development of nanomedicine has brought a new dawn to cartilage tissue engineering, and composite hydrogel containing nanoparticles can substantially mimic natural cartilage components with good histocompatibility, demonstrating unique biological effects. In this review, we summarize the different advanced nanoparticle hydrogels currently adopted in cartilage tissue engineering. In addition, we also discuss the various application scenarios including injection and fabrication strategies of nanocomposite hydrogel in the field of cartilage repair. Finally, the future application prospects and challenges of nanocomposite hydrogel are also highlighted.https://www.frontiersin.org/articles/10.3389/fbioe.2022.951513/fullnanoparticlescomposite hydrogelstissue engineeringcartilagerepairing |
| spellingShingle | Yunong Ao En Zhang Yangxi Liu Liu Yang Jun Li Jun Li Fuyou Wang Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering Frontiers in Bioengineering and Biotechnology nanoparticles composite hydrogels tissue engineering cartilage repairing |
| title | Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering |
| title_full | Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering |
| title_fullStr | Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering |
| title_full_unstemmed | Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering |
| title_short | Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering |
| title_sort | advanced hydrogels with nanoparticle inclusion for cartilage tissue engineering |
| topic | nanoparticles composite hydrogels tissue engineering cartilage repairing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.951513/full |
| work_keys_str_mv | AT yunongao advancedhydrogelswithnanoparticleinclusionforcartilagetissueengineering AT enzhang advancedhydrogelswithnanoparticleinclusionforcartilagetissueengineering AT yangxiliu advancedhydrogelswithnanoparticleinclusionforcartilagetissueengineering AT liuyang advancedhydrogelswithnanoparticleinclusionforcartilagetissueengineering AT junli advancedhydrogelswithnanoparticleinclusionforcartilagetissueengineering AT junli advancedhydrogelswithnanoparticleinclusionforcartilagetissueengineering AT fuyouwang advancedhydrogelswithnanoparticleinclusionforcartilagetissueengineering |