Different TERT Expression between Colorectal Adenoma and Serrated Polyp
<i>Background and Objectives:</i> Telomere regulation have an association with colorectal cancer. Previous studies demonstrated its implication in colorectal carcinogenesis. This study aimed to identify the role of telomerase reverse transcriptase (TERT) in colorectal carcinogenesis and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/56/9/463 |
| _version_ | 1797721505566556160 |
|---|---|
| author | Soo-Jung Jung Jae-Hee Park Ilseon Hwang Jae-Ho Lee |
| author_facet | Soo-Jung Jung Jae-Hee Park Ilseon Hwang Jae-Ho Lee |
| author_sort | Soo-Jung Jung |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Telomere regulation have an association with colorectal cancer. Previous studies demonstrated its implication in colorectal carcinogenesis. This study aimed to identify the role of telomerase reverse transcriptase (TERT) in colorectal carcinogenesis and determine TERT expression and their associated genes in precancerous lesions. <i>Materials and Methods:</i> TERT expression in 93 colorectal precursor lesions was analyzed. This included 61 tubular adenomas (TAs) and 32 serrated polyps (SPs). Furthermore, KRAS and BRAF gene mutations and microsatellite instability were analyzed. Statistical tests were performed to analyze the relationship between variables. <i>Results:</i> TERT expression in TAs, when compared with those observed in paired adjacent nontumor tissues, was 0.92 ± 0.78. TERT expression levels were significantly lower in SPs (0.38 ± 0.14, <i>p</i> < 0.001). KRAS and BRAF mutations were mutually exclusive in TAs and SPs (<i>p</i> < 0.001). TERT expression tended to be associated with KRAS mutations (46.7% vs. 22.0%, <i>p</i> = 0.098) and low-grade tumors (35.0% vs. 16.0%, <i>p</i> = 0.096), but this difference was insignificant. <i>Conclusions:</i> TERT expression has a pivotal role in progression to TAs in colorectal tissue. Considering the association between TERT expression and KRAS mutation, therapeutic drugs targeting this pathway can be developed for cancer prevention. |
| first_indexed | 2024-03-12T09:35:15Z |
| format | Article |
| id | doaj.art-8ff658348990486fadb46658225332de |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:35:15Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-8ff658348990486fadb46658225332de2023-09-02T13:46:36ZengMDPI AGMedicina1010-660X2020-09-015646346310.3390/medicina56090463Different TERT Expression between Colorectal Adenoma and Serrated PolypSoo-Jung Jung0Jae-Hee Park1Ilseon Hwang2Jae-Ho Lee3Department of Anatomy, School of Medicine, Keimyung University, Daegu 42061, KoreaDepartment of Anatomy, School of Medicine, Keimyung University, Daegu 42061, KoreaDepartment of Pathology, School of Medicine, Keimyung University, Dongsan Medical Center, Daegu 42061, KoreaDepartment of Anatomy, School of Medicine, Keimyung University, Daegu 42061, Korea<i>Background and Objectives:</i> Telomere regulation have an association with colorectal cancer. Previous studies demonstrated its implication in colorectal carcinogenesis. This study aimed to identify the role of telomerase reverse transcriptase (TERT) in colorectal carcinogenesis and determine TERT expression and their associated genes in precancerous lesions. <i>Materials and Methods:</i> TERT expression in 93 colorectal precursor lesions was analyzed. This included 61 tubular adenomas (TAs) and 32 serrated polyps (SPs). Furthermore, KRAS and BRAF gene mutations and microsatellite instability were analyzed. Statistical tests were performed to analyze the relationship between variables. <i>Results:</i> TERT expression in TAs, when compared with those observed in paired adjacent nontumor tissues, was 0.92 ± 0.78. TERT expression levels were significantly lower in SPs (0.38 ± 0.14, <i>p</i> < 0.001). KRAS and BRAF mutations were mutually exclusive in TAs and SPs (<i>p</i> < 0.001). TERT expression tended to be associated with KRAS mutations (46.7% vs. 22.0%, <i>p</i> = 0.098) and low-grade tumors (35.0% vs. 16.0%, <i>p</i> = 0.096), but this difference was insignificant. <i>Conclusions:</i> TERT expression has a pivotal role in progression to TAs in colorectal tissue. Considering the association between TERT expression and KRAS mutation, therapeutic drugs targeting this pathway can be developed for cancer prevention.https://www.mdpi.com/1010-660X/56/9/463TERTcolorectal cancertubular adenomaserrated polyp |
| spellingShingle | Soo-Jung Jung Jae-Hee Park Ilseon Hwang Jae-Ho Lee Different TERT Expression between Colorectal Adenoma and Serrated Polyp Medicina TERT colorectal cancer tubular adenoma serrated polyp |
| title | Different TERT Expression between Colorectal Adenoma and Serrated Polyp |
| title_full | Different TERT Expression between Colorectal Adenoma and Serrated Polyp |
| title_fullStr | Different TERT Expression between Colorectal Adenoma and Serrated Polyp |
| title_full_unstemmed | Different TERT Expression between Colorectal Adenoma and Serrated Polyp |
| title_short | Different TERT Expression between Colorectal Adenoma and Serrated Polyp |
| title_sort | different tert expression between colorectal adenoma and serrated polyp |
| topic | TERT colorectal cancer tubular adenoma serrated polyp |
| url | https://www.mdpi.com/1010-660X/56/9/463 |
| work_keys_str_mv | AT soojungjung differenttertexpressionbetweencolorectaladenomaandserratedpolyp AT jaeheepark differenttertexpressionbetweencolorectaladenomaandserratedpolyp AT ilseonhwang differenttertexpressionbetweencolorectaladenomaandserratedpolyp AT jaeholee differenttertexpressionbetweencolorectaladenomaandserratedpolyp |