| Summary: | This systematic review (SR) and meta-analysis (MA) aimed to compare the treatment effects of orthognathic surgery and orthodontic camouflage treatment in adult subjects with Class III malocclusion (C-III-M). Two independent reviewers conducted the literature search comprehensively from 1990 to 8 November 2021. PubMed, Science Direct, Scopus, EBSCOhost and Google Scholar databases were included for literature search. Moreover, a manual search of references from relevant studies was performed. Based on the literature search, a total of six articles were selected for SR and three articles fulfilled the criteria of a MA. Standardized mean difference (SMD) was used to evaluate and compare the treatment effects of orthodontic camouflage treatment and orthognathic surgery in adult C-III-M patients. Test for overall effect from the studies was used to estimate the treatment effect of C-III-M. However, Significant heterogeneity and publication bias was apparent among the selected studies. More research on the treatment effects of orthodontic camouflage treatment and orthognathic surgery in C-III-M is necessary to conclude possible interactions with better specificity.
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