IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application

IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application

Previously, we showed that mouse immunity-related guanosine triphosphatase (GTPase) family M protein 1 (Irgm1) promotes malignant melanoma progression by inducing cellular autophagy flux and metastasis. Human IRGM, a truncated protein functionally distinct from its mouse counterpart, has several spl...

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Bibliographic Details
Main Authors: Linlu Tian, Hongxue Meng, Xiao Dong, Xinlei Li, Zilin Shi, Hulun Li, Lie Zhang, Yue Yang, Ruijie Liu, Chunying Pei, Bo Li, Hongwei Xu, Rui Li
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
Melanoma
IRGM
autophagy
prognostic biomaker
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301789

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