Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity
Aim. To elucidate therapeutic effect of metformin-sitaglitin combination on the dynamics of indices of insulin resistance and functional activity of pancreaticbeta-cells, lipid metabolism and body weight in patients with type 2 diabetes mellitus (DM2) and obesity. Materials and methods. The study...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2010-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5490 |
| _version_ | 1797255288157372416 |
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| author | Alexander Sergeevich Ametov Elena Nikolaevna Pakus |
| author_facet | Alexander Sergeevich Ametov Elena Nikolaevna Pakus |
| author_sort | Alexander Sergeevich Ametov |
| collection | DOAJ |
| description | Aim. To elucidate therapeutic effect of metformin-sitaglitin combination on the dynamics of indices of insulin resistance and functional activity of pancreaticbeta-cells, lipid metabolism and body weight in patients with type 2 diabetes mellitus (DM2) and obesity. Materials and methods. The study included 32 patients treated by a combination of metformin (500-2550 mg/day) and sitagliptin (100 mg) for18 weeks. Standard parameters of carbohydrate and lipid metabolism, body mass index (BMI), blood adiponectin and leptin levels were measured, indices of insulin resistance and functional activity of pancreatic beta-cells were calculated. Results. Therapy with metformin-sitagliptin combination ensured compensation of fasting and postprandial hyperglycemia, reduced HbA1c level, increasedfunctional activity of beta-cells, decreased peripheral insulin resistance and BMI, had beneficial effect on lipid metabolism and hormonalactivity of adipose tissue. Conclusion. Metformin-sitagliptin combination can be recommended as a clinically efficacious modality for the treatment of patients with diabetesmellitus and obesity. |
| first_indexed | 2024-03-08T15:22:30Z |
| format | Article |
| id | doaj.art-8ffa4d0318294f518682a1bd04185873 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:28Z |
| publishDate | 2010-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-8ffa4d0318294f518682a1bd041858732024-03-20T11:47:56ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782010-09-01133626510.14341/2072-0351-54905448Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesityAlexander Sergeevich Ametov0Elena Nikolaevna Pakus1ГОУ ДПО Российская медицинская академия последипломного образования, МоскваГОУ ДПО Российская медицинская академия последипломного образования, МоскваAim. To elucidate therapeutic effect of metformin-sitaglitin combination on the dynamics of indices of insulin resistance and functional activity of pancreaticbeta-cells, lipid metabolism and body weight in patients with type 2 diabetes mellitus (DM2) and obesity. Materials and methods. The study included 32 patients treated by a combination of metformin (500-2550 mg/day) and sitagliptin (100 mg) for18 weeks. Standard parameters of carbohydrate and lipid metabolism, body mass index (BMI), blood adiponectin and leptin levels were measured, indices of insulin resistance and functional activity of pancreatic beta-cells were calculated. Results. Therapy with metformin-sitagliptin combination ensured compensation of fasting and postprandial hyperglycemia, reduced HbA1c level, increasedfunctional activity of beta-cells, decreased peripheral insulin resistance and BMI, had beneficial effect on lipid metabolism and hormonalactivity of adipose tissue. Conclusion. Metformin-sitagliptin combination can be recommended as a clinically efficacious modality for the treatment of patients with diabetesmellitus and obesity.https://www.dia-endojournals.ru/jour/article/view/5490type 2 diabetes mellitusobesitymetforminsitagliptin |
| spellingShingle | Alexander Sergeevich Ametov Elena Nikolaevna Pakus Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity Сахарный диабет type 2 diabetes mellitus obesity metformin sitagliptin |
| title | Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity |
| title_full | Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity |
| title_fullStr | Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity |
| title_full_unstemmed | Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity |
| title_short | Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity |
| title_sort | efficacy and safety of metformin sitagliptin combination for the treatment of patients with diabetes mellitus and obesity |
| topic | type 2 diabetes mellitus obesity metformin sitagliptin |
| url | https://www.dia-endojournals.ru/jour/article/view/5490 |
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